FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Comparatismi, 2018 What is literature for us today? And what will become of it in the next few years? Our era only seems willing to recognize the complexity of the field of science; whereas as far as literature is concerned, it is still thought that a rigorous training is not necessary and many deceive themselves into thinking that it is possible to do without the ...
openaire +3 more sources
Mergers and Acquisitions: revisiting the human factor in the light of a knowledge-based view of the firm and complexity theory [PDF]
An ongoing argument in the MetA literature is that the human factor has an important impact on the outcome of those operations. Analysis of the HR integration has identified human factors that play an inhibiting role on post-acquisition performance ...
Nicola Mirc
core
LITERARY COMPETENCE OF FUTURE PHILOLOGY TEACHERS' PROFESSIONAL DEVELOPMENT (BASED ON THE EDUCATIONAL EXPERIENCE OF GERMANY) [PDF]
, 2015 The author performs a theoretical analysis of the educational experience in philology teachers' professional training in Germany in the context of solving scientific problem of literary competence development.
Базиль, Людмила Олександрівна
core
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Jeffrey R. Di Leo (ed.), Theory as World Literature, New York: Bloomsbury Academic, 2025, 284 p.
Studia Universitatis Babeş-Bolyai. PhilologiaTheory as literature: it is easy enough to grasp how these two terms may admit to a relationship of sorts. Certainly, one may very well reject this ‘as’, in an understandable attempt to starkly differentiate the two registers, drawing a line between ...
Codrin ANICULĂESE
doaj
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Faith in development : what difference does faith make for Christian NGOs working in Bangladesh? : a research thesis presented in partial fulfilment of the requirements for the degree of Master of International Development at Massey University, Palmerston North, New Zealand [PDF]
, 2018 Religious organisations are the oldest social service networks known to humankind. However, the underlying topic of religion and development has been mostly ignored in development literature until more recently.
Doorey, Julian Samuel
core
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source