Results 91 to 100 of about 518,211 (354)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Literackie konstrukcje traumy kulturowej: ideologiczny wymiar ‘kobiet w żałobie’ w powieściach Roberta Edrica In Desolate Heaven oraz Jodie Shields The Crimson Portrait

open access: yesTeksty Drugie, 2018
Trauma theories have proven an immensely influential framework in the humanities. However, contemporary fictional representations of the Great War all too often focus on soldiers or veterans as the traumatized victims.
Marzena Sokołowska-Paryż
doaj  

The Portrayal of National Identity in the Films of Małgorzata Szumowska

open access: yesSprawy Narodowościowe. Seria nowa, 2017
The Portrayal of National Identity in the Films of Małgorzata Szumowska Małgorzata Szumowska is without a doubt one of a few Polish directors who has managed to distinguish herself on the European film market.
Grzegorz Wójcik
doaj   +1 more source

‘Together in Work, but Alone at Heart’: Insider Perspectives on the Mental Health of British Police Officers [PDF]

open access: yes, 2018
This research explored the mental health of British police. Interviews with six officers, of varying rank, were conducted to explore the nature, prevalence and causes of mental health issues amongst colleagues.
Jenkins, Molly, Turner, Tim
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Cosmopolitan Society and its Enemies

open access: yesCosmopolitan Civil Societies: An Interdisciplinary Journal
Since the end of the Cold War, the world has not abandoned ‘the dream of cosmopolitan peace’ (Alexander 2005). The adjective ‘cosmopolitan’ refers to the political and philosophical concept that all human beings are members of a single community.
Kazuma Matoba
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Addressing Trauma Among Gay, Bisexual, and Queer Boys of Color [PDF]

open access: yes, 2016
A growing body of research reveals that lesbian, gay, bisexual, transgender, and queer (LGBTQ) people experience a disproportionate amount of mental health challenges when compared with those who are heterosexual and cisgender.
Kevin L. Nadel
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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