Results 121 to 130 of about 3,132,133 (305)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

10 years’ cultural variation of Croatia from pre to post accession: the changed value and unchanged cultural position

Frontiers in Sociology
IntroductionCroatia’s accession to the European Union (EU) in 2013 completed its institutional integration; however, the alignment of its social and cultural values with those of other EU member states remains an ongoing process.MethodsUtilizing Hofstede’
Chunyan Wang, Ivica Bakota, Ivana Buljan, Yuhong Shang   +3 more
doaj   +1 more source

The economic value of virtue [PDF]

We model virtue as an asset on the marriage market : since men value virginity in prospective mates, preserving their virtue increases girls' chances of getting a "good" husband, and therefore allows for upward social mobility.
Fabio Mariani
core  

Not Untitled. [PDF]

, 2012
This chapter situates my own practice within an emergent field of urban intervention. It discusses the process, value of and inherent dangers in reframing interventionist practices and generating critical discourse around the 'invisible' and 'unofficial,'
McCaughey, Peter
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Home-School Cultural Value Mismatch: Antecedents and Consequences in a Multi-Ethnic Sample Transitioning to College. [PDF]

Front Psychol, 2021
Vasquez-Salgado Y, Greenfield PM, Guan SA.   +2 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Relationship Between Smoker Identity and Smoking Cessation Among Young Smokers: The Role of Smoking Rationalization Beliefs and Cultural Value of Guanxi. [PDF]

Front Psychiatry, 2022
Chen H, Fan Y, Li X, Gao L, Li W.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Economic Value of Cultural Diversity: Evidence from US Cities [PDF]

What are the economic consequences to U.S. natives of the growing diversity of American cities? Is their productivity or utility affected by cultural diversity as measured by diversity of countries of birth of U.S. residents?
Gianmarco I.P. Ottaviano, Giovanni Peri
core