Results 161 to 170 of about 581,686 (314)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Situated cultural approach versu predefined cultural archetypes models

open access: yes, 2009
Within the last 20 years, the practical relevance of researching cultural issues, and especially comparing phenomena across cultures, was questioned (Ferraro, 1990).
Ali, M
core  

Cultures and Values

open access: yes
Abstract Working with a minimal theory of culture, according to which cultures are group-level patterns of specific types of activities, together with a modest theory of values as features that figure in reasons to promote or inhibit, this chapter provides constitutive accounts of hedonic, aesthetic, and artistic cultures, each organized
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Culturally-attuned AI: Implicit learning of altruistic cultural values through inverse reinforcement learning. [PDF]

open access: yesPLoS One
Oliveira N   +6 more
europepmc   +1 more source

Sharing of cultural values and heritage through storytelling in the digital age. [PDF]

open access: yesFront Psychol, 2023
Zort Ç   +3 more
europepmc   +1 more source

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