Results 81 to 90 of about 27,308 (167)
IGBO DIASPORA SUSCEPTIBILITY TO WESTERN CULTURAL VALUES
African And Global Issues QuarterlyMigration had always been integral to Igbo history during the Pre-Colonial, Colonial and Post-Colonial eras. However, the aftermath of the Nigerian Civil War had maximally influenced the rate of International migratory behaviour among the Igbo ...
Boniface Ifeanyi Orji +1 more
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Emotions and Emotion-Related Values in Cultural Heritage
EncyclopediaEmotions are relatively brief, object-directed affective episodes that arise when a person appraises an event, place, object, or memory as relevant to their concerns, and that unfold across several coordinated components: cognitive appraisal ...
Matthias Ripp, Rayee Metha
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Research in English Language PedagogyWith the introduction of cultural linguistics by Ronald Langacker (1994) and Gary B. Palmer (1996) and Farzad Sharifian’s (2017) expansion of the field through the development of the analytical framework of cultural conceptualizations, scholars ...
Ali Dabbagh
doaj
“The Canterbury Tales” by Geoffrey Chaucer: Classic “Text-code” and Universal Cultural Phenomenon
Polylinguality and Transcultural Practices“The Canterbury Tales”, written over 600 years ago, is considered to be one of the books that changed the world, and its author, the English poet Geoffrey Chaucer, is believed to be the writer who united generations. It is the “Canterbury Tales” that the
Natalia V. Khudolei +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source