Results 71 to 80 of about 76,082 (262)

Culture and Violence

Etnoantropološki Problemi, 2012
Saša Nedeljković. Kultura i nasilje: antropološki pristup proučavanju naličja nasilja. 2011. Beograd: Baštinik i Odeljenje za etnologiju i antropologiju Filozofskog fakulteta u Beogradu, str. 518. (Saša Nedeljković, Culture and Violence: An Anthropological Approach to the Study of the Face of Violence, Belgrade, 2011)
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Violence Against Administrators: The Roles of Student, School, and Community Strengths and Cultural Pluralism

Behavioral Sciences
Scientific and public attention regarding educator-directed violence has increased over the past 15 years; however, research on violence against administrators is limited.
Susan D. McMahon, Andrew H. Perry, Taylor Swenski, Kailyn Bare, Jared Hunt, Andrew Martinez, Linda A. Reddy, Eric M. Anderman, Ron Avi Astor, Dorothy L. Espelage, Frank C. Worrell, Christopher M. Dudek   +11 more
doaj   +1 more source

A Predictive Model of Domestic Violence in Multicultural Families Focusing on Perpetrator

Asian Nursing Research, 2016
Purpose: This study was conducted to assess predictor variables of husbands in multicultural families and examine the relationship among variables after setting up a hypothetical model including influencing factors, so as to provide a framework necessary
Eun Young Choi, RN, PhD, Hye Jin Hyun, RN, PhD   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Attitudes Regarding Gender Roles and Recurrence of Dating Violence in Spanish and Mexican Adolescents

Societies
Gender-based violence is recognized as both a violation of human rights and a significant public health problem due to its widespread prevalence. Gender-based violence has also been shown to be associated with sexist beliefs.
María de la Villa Moral-Jiménez, Aitana Alvarez-Menéndez, Francisco Javier Rodríguez-Díaz   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Hejt wobec twórców i instytucji kultury: nowe oblicza przemocy w epoce cyfrowej – rozważania wstępne

Zarządzanie w Kulturze
The article offers a preliminary attempt to formulate a thesis that hate directed at artists and cultural institutions in Poland may be understood as one of the significant contemporary forms of ...
Marta Seredyńska
doaj   +1 more source