Results 101 to 110 of about 15,265,163 (397)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Confronting “Culture” in Medicineʼs “Culture of No Culture”

open access: yesAcademic Medicine, 2003
The author presents reflections from medical anthropology on the institutional culture of medicine and medical education, which sees itself as a "culture of no culture" and which systematically tends to foster static and essentialist conceptions of "culture" as applied to patients.
openaire   +3 more sources

Culture and Learning [PDF]

open access: yes, 2010
Ensuring "the development of the child ... to the maximum extent possible" is part of every child’s rights under the UN Convention on the Rights of the Child.

core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Singularidades e diversidades do artesanato norte-rio-grandense

open access: yesConfins, 2017
The understanding of the construction of local development strategies backed by creativity reveals that social practices are the condition for a more dignified life, and a counterpoint to the hegemonic restructuring movement.
Alessandro Dozena
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Examining the Results of Antibiogram in the Urine Cultures of 1-12-Year-Old Children with Urinary Tract Infections Hospitalized in Affiliated Hospitals of Islamic Azad University of Medical Sciences، Tehran، 2021-2022 [PDF]

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: The widespread occurrence of urinary tract infections, challenges in clinical and laboratory diagnosis, varying the clinical manifestations across different age groups, and antibiotic resistance in various regions and studies in recent ...
Parisa Jalili   +2 more
doaj  

Kültürel Hegemonya’nın Hollywood Sinema Filmleri Üzerinden İnşası

open access: yesErciyes İletişim Dergisi
Siyasal iktidarın sürdürülebilirliği onun arzuladığı değerler sisteminin kabulü ile mümkün olmaktadır. Hollywood film endüstrisi ve onun bir ürünü olan sinema mesafe ve sınır tanımaksızın ulaştığı her noktada zihinsel bir inşa eylemi gerçekleştirmektedir.
Ibrahim Dalkilic
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Culture and Territorial Identity: An Analysis Based on the Organization of Pedagogical Work in Rural Education

open access: yesRevista Brasileira de Educação do Campo
The general objective is to analyze, through a systematic review of academic literature (2009–2024), how the organization of pedagogical work in Rural Education has been conceived and practiced, highlighting its relationship with cultural processes and ...
Rodrigo Cardoso da Silva   +1 more
doaj   +1 more source

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