Results 141 to 150 of about 14,735,798 (370)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Cuando el traductor empieza a inventar: creaci\uf3n l\ue9xica en la versi\uf3n espa\uf1ola de Baudolino de Umberto Eco [PDF]

open access: yes, 2007
In questo saggio si riflette sull'esperienza della traduzione dei dialettalismi e delle lingue inventate nella versione spagnola di "Baudolino" di Umberto Eco.Partendo dalla funzione umoristica e parodica e passando dagli esercizi letterari metasemantici,
Lozano Miralles H.
core  

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

Specific features of cognitive skill development in athletes of situational sports

open access: yesPedagogy of Physical Culture and Sports
Background and Study Aim. The formation of cognitive skills in athletes engaged in situational sports follows specific patterns determined by the characteristics of gameplay or competitive activity, as well as by the influence of psychophysiological and ...
Vyacheslav Romanenko   +6 more
doaj   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

open access: yesMolecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza   +3 more
wiley   +1 more source

Interview with Carl Sandler, CEO of MISTER ® [PDF]

open access: yesDigital Culture & Education, 2014
Digital Culture & Education
doaj  

Chiffres-clés du secteur du livre 2016-2017 [PDF]

open access: yes
Les Chiffres clés du secteur du livre sont publiés chaque année à la veille du Salon du livre de Paris par l’Observatoire de l’économie du livre du Service du livre et de la lecture de la DGMIC. Ils présentent en 4 pages les données statistiques les plus
Ministère de la Culture
core  

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