Results 51 to 60 of about 3,473,124 (209)

Objective criteria for determination of functional-reserve potentials of secondary school age pupils

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2015
Purpose: to substantiate criteria for determination of functional-reserve potentials of secondary school age pupils. Material: 1017 pupils of 5-9 forms from 16 schools were questioned.
I.R. Bodnar, O.V. Rymar, A.V. Solovei, G.G. Malanchuk, P.P. Datskiv   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integration of In Vitro Approaches With Whole-Genome Sequencing to Evaluate the Probiotic Potential of Lactic Acid Bacteria Isolated From Thit Chua: A Traditional Fermented Sour Meat in Northwest Vietnam

International Journal of Microbiology
Human demand for safe and high-quality fermented meat products has been increasing, emphasizing the need to develop innovative production approaches that incorporate functional starter cultures.
Nhung Thi Doan, Ha Viet Nguyen, Huy Duc Bui, Van Thi Nguyen, Linh Hai Nguyen Bui, Lan Anh Thi Hoang, Trung Thanh Trinh   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Beyond Compliance: Harnessing the Power of Internal Public Audits for Sustainability Management Excellence

Annals of Spiru Haret University Economic Series
In today's rapidly evolving business landscape, sustainability has emerged as a critical imperative for organizations worldwide. Beyond mere regulatory compliance, sustainability encompasses a holistic approach to environmental, social, and governance ...
Elena GURGU, Radu Ioan PODGOREANU, Marina DRAGAN, Aura NEAGA   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Model Characteristics of Psychophysiological Indicators of Volleyball Players in the Specialized Training Group

Sportivnye igry
Purpose: to develop model characteristics of psychophysiological indicators of volleyball players in the specialized training group. Materials and Methods. Ten male volleyball players participated in the study (training experience: 5-6 years; age: 15,9±0,
Volodymyr Paievskyi, Maksym Merzlikin, Yura Tropin, Vyacheslav Romanenko, Natalya Boychenko   +4 more
doaj   +1 more source