Results 191 to 200 of about 168,599,081 (252)

Transduction efficiency in clinical CAR T cell products: A retrospective study at a single center. [PDF]

Mol Ther Adv
Shao L, Prochazkova M, Cai Y, Lee Han K, Martin K, Shi R, Yang R, Ma J, Zheng Y, Garces P, Frodigh SE, Pham V, Zhang N, Somerville RP, Stroncek DF, Jin P.   +15 more
europepmc   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Ecofeminist heterotopias: gendered ecologies, memory, and ecological displacement in Elif Shafak's <i>There Are Rivers in the Sky</i>. [PDF]

Front Sociol
S H, S P.
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Targeting PKM2 Enhances the Anti-Tumor Function of CD8⁺ T Cells Through Metabolic Reprogramming. [PDF]

Int J Mol Sci
Zhang J, Wu S, Yin Q, Liu Y, Zheng S, Yang P.   +5 more
europepmc   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations. [PDF]

NPJ Vaccines
Balkhi MY, Kalyanasundaram A, Arya A, Kifle DW, Mckinnon M, Krishnappa D, Shrivastava H, Siribie M, Aziz A, Jeon H, Yongchaitrakul T, Tadesse BT, Rakotozandrindrainy N, Razafimanantsoa R, Noellie HB, Ouedraogo NI, Diarra A, Gray SA, Coler RN, Lee J, Rakotozandrindrainy R, Sirima SB, Jackson LA, Marks F, Carter D, Siddiqui AA.   +25 more
europepmc   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source