Results 51 to 60 of about 39,746 (312)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Report of the Secretary-General on the Colloquium on Science and Technology as Basis for African Development [PDF]

open access: yes, 1982
Council of Ministers Thirty-Ninth Ordinary Session Tripoli, Libya 26 July - 2 August 1982This is a report on the proceedings of the colloquium on "Science and Culture as basis for African Development" which was held in Libreville, Gabon, from 23 .to 27 ...
Organization of African Unity
core  

BRIDGING THE COMPETING VIEWS OF EUROPEAN CULTURAL INTEGRATION: THE TRANSFORMATIVE VIEW OF CULTURE AS A MEANS TO PROMOTE GROWTH, EMPLOYMENT AND SOCIAL COHESION [PDF]

open access: yesChallenges of the Knowledge Society, 2018
The concept of a European culture became very complex with the enlargement of 2004 towards the East, when the EU, as Delanty pointed out, moved “beyond postnationality to an encounter with multiple civilizational forms,” multiple histories and ...
María Luz SUÁREZ CASTIÑEIRA
doaj  

Spirituality of unity in management - Economy of Communion

open access: yesCogent Business & Management, 2016
The spirituality of unity in management processes is presented in the paper. The idea of the Economy of Communion (EoC) project and its realization in more than 800 businesses worldwide as an example of the striving for the eradication of poverty and new
Stanisław Grochmal
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Ontology of Language and Culture in Philosophy of Name by A. F. Losev

open access: yesКонцепт: философия, религия, культура
The relevance of the study is due to the necessity to analyze mutual determination of the development of language and culture so as to expand the problematic field of humanities.
O. Yu. Astakhov, O. V. Rtishcheva
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Report of the Sixth Session of the Scientific Council for Africa [PDF]

open access: yes, 1981
Council of Ministers Thirty-Seventh Ordinary Session Nairobi, Kenya 15 - 21 June 1981This is a report on the proceedings of the Sixth Session of the Scientific Council for Africa which was held in Libreville, Gabon from 28 January to 1 February 1981 to ...
Organization of African Unity
core  

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