Results 141 to 150 of about 964,619 (305)

Prioritisation of pesticides and target organ systems for dietary cumulative risk assessment based on the 2019–2021 monitoring cycle

EFSA Journal
Aiming at accelerating the implementation of cumulative risk assessment to pesticide residues, this report describes a two‐step prioritisation analysis, on individual pesticides and on target organ systems, that allows to identify (i) low‐priority ...
European Food Safety Authority (EFSA), Giulio Di Piazza, Bruno Dujardin, Sara Levorato, Paula Medina, Luc Mohimont, Efisio Solazzo, Violetta Costanzo   +7 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Normal hexane occupational exposure estimation in the benchmark response according to color vision impairment

Salāmat-i kār-i Īrān, 2018
Background and aims: Exposure to the normal hexane can induce dysfunction of the nervous system and color vision impairment. Occupational risk assessment is established according to no observed adverse effect levels (NOAEL).
Rezvan Zendedel, Zahra Panjali, akbar Esmaeeli Tahneh   +2 more
doaj  

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank

BMJ Open
Objectives HFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y and p.H63D variant cumulative incidence of multiple clinical outcomes in a large community ...
Luke C Pilling, David Melzer, Janice L Atkins, Mitchell R Lucas, Jeremy D Shearman   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The role of federal guidelines in the Evolution of cumulative effects assessment research in the Canadian forest ecosystem

Ecological Indicators
Cumulative effects assessment (CEA), as a subset of environmental impact assessment, has been used over the past half-century to evaluate the impact of anthropogenic and natural processes on the integrity of forest ecosystems.
Effah Kwabena Antwi, Priscilla Toloo Yohuno (Apronti), John Boakye-Danquah, Evisa Abolina, Anna Dabros, Akua Nyamekye Darko   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Links Among Cumulative Ecological Risk and Smartphone Addiction, Sleep Quality in Chinese University Freshmen: A Two-Wave Study

Psychology Research and Behavior Management
Yuntian Xie, Feiyan Zeng, Zhou Dai Department of Applied Psychology, Changsha Normal University, Changsha, People’s Republic of ChinaCorrespondence: Yuntian Xie, Department of Applied Psychology, Changsha Normal University, No.
Xie Y, Zeng F, Dai Z
doaj