Results 91 to 100 of about 194,005 (197)

Oxygen-based soft-sensing of glucose demand in Chinese hamster ovary fed-batch cultures across scales

Applied Microbiology and Biotechnology
Glucose is a critical nutrient in mammalian cell culture processes, influencing cellular metabolism, productivity, and product quality. In industrial Chinese hamster ovary (CHO) fed-batch processes, glucose concentrations are commonly controlled using ...
Valentin Jossen, Adrian Joseph, Gonzalo Mesado, Siewhoon Lim, Gilles Broccard   +4 more
doaj   +1 more source

Short-term vs. overnight insemination: which one is better for patients with only one or two oocytes retrieved in IVF cycles?

Frontiers in Endocrinology
BackgroundCompared with overnight insemination, it remains uncertain whether short-term insemination can improve outcomes in poor responders, and few studies have used cumulative live birth rate as the primary endpoint.
Jinghua Chen, Zhenfang Liu, Jiali Cai, Jiali Cai, Xiaoming Jiang, Xiaoming Jiang, Luxiang Pan, Liying Zhou, Kaijie Chen, Xiaolian Yang, Yurong Chen, Lanlan Liu, Lanlan Liu, Jianzhi Ren   +13 more
doaj   +1 more source

When does cultural evolution become cumulative culture? A case study of humpback whale song. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Garland EC, Garrigue C, Noad MJ.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The sequential use of IVF disposable devices doesn’t cause cumulative toxicity unless a defective device compromises the entire procedure

Scientific Reports
This study investigated whether the sequential use of disposable devices in routine IVF procedures induces cumulative embryotoxicity. Ten combinations, each including 7 to 25 disposables covering essential IVF steps—sperm collection, oocyte retrieval ...
Lucie Delaroche, Lucile Besnard, Fabienne Bazin, Enric Mestres, Monica Acacio, Nuno Costa-Borges   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Effect of Phosalone as an Organophosphate Pesticide with Different Levels of Bentonite on Fermentation Parameters of a TMR Ration According to in vitro Condition

پژوهشهای علوم دامی ایران, 2016
In this experiment, fermentation parameters of a TMR ration determined with different levels of phosalone as an organophosphate pesticide (0, 100, 250, 500, 750 and 1000 ppm) and bentonite (0, 1 and 2 %DM of TMR) using in vitro batch culture and gas ...
M. Kazemi, A.M. Tahmasbi, R. Valizadeh, A.A. Naserian, R. Afshari, A. Sonei   +5 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source