Results 21 to 30 of about 233,302 (259)

A Physically Based Cumulative Damage Formalism [PDF]

International Journal of Fatigue, 2008
A general cumulative damage methodology is derived from the basic relation specifying crack growth rate (increment) as a power law function of the stress intensity factor. The crack is allowed to grow up to the point at which it becomes unstable, thereby determining the lifetime of the material under the prescribed stress program. The formalism applies
openaire   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Cumulative Fatigue Damage Under stepwise Tension-Compression Loading [PDF]

International Journal of Mining and Geo-Engineering, 2018
Rock structures are subjected to cyclic tension-compression loading due to a blasting, earthquake, traffic and injection-production in underground storage case.
Hadi Haghgouei, Hamid Hashemolhosseini, Alireza Baghbanan   +2 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Maximum Operational Fluence Limits for Temporally Shaped Nanosecond Long Pulses

Applied Sciences
The maximum energy at which a laser can be operated safely is a matter of paramount importance. This is patently related to laser induced damage. In the nanosecond regime, this poses a unique challenge, as it is not solely influenced by laser intensity ...
Pedro Oliveira, Mario Galletti, Cosmin Suciu, Marco Galimberti   +3 more
doaj   +1 more source

Cumulative damage and stability analysis of bedding rock slope under frequent microseisms

Yantu gongcheng xuebao, 2020
Micro-seism frequently occurs in the Three Gorges Reservoir after impoundment and has a significant impact on slope stability. To investigate the cumulative damage and stability of typical bedding rock slope under frequent microseisms, the shaking table ...
LIU Xin-rong 1, 2, 3, XU Bin 1, 2, 3, LIU Yong-quan 4, WANG Ji-wen 1, 2, 3, LIN Guang-yi 1, 2, 3
doaj   +1 more source

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia, Tarique Hussain, Jeanne Dillenbeck, Matthew Hammer, Annette von Drygalski, Guy Young, Ayesha Zia   +6 more
wiley   +1 more source

Service Life Evaluation of Curved Intercity Rail Bridges Based on Fatigue Failure

Infrastructures
There are curved bridge structures in the intercity rail line. During the operation of bridges, they are subjected to train loads, resulting in stress amplitudes of the construction materials; during operation, when the train interval is short, the ...
Hongwei Zhang, Shaolin Chen, Wei Zhang, Xiang Liu   +3 more
doaj   +1 more source

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Anthracycline‐related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient‐specific factors, moderate‐to‐vigorous physical activity (MVPA), and cardiac remodeling.
Hari K. Narayan, Sitong Chen, F. Lennie Wong, Nathan Young, Anna Qi, Christopher Davis, Sanjeet Hegde, Nicholas Gloude, Kasey J. Leger, Kelly D. Getz, Francisco Contijoch, Kirsten Ness, Bonnie Ky, Dennis Kuo, Sheri J. Hartman, Saro H. Armenian   +15 more
wiley   +1 more source