Results 31 to 40 of about 25,887 (256)

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Fatigue Strength Assessment of an Aluminium Alloy Car Body Using Multiaxial Criteria and Cumulative Fatigue Damage Theory

Applied Sciences, 2022
With the rapid development of urban rail transit, metro vehicles have become preferred choices for urban transportation. It is important to accurately evaluate the fatigue strength of a car body to ensure subway safety.
Yiming Shangguan, Wenjing Wang, Chao Yang, Anrui He   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

New Nonlinear Cumulative Fatigue Damage Model Based on Ecological Quality Dissipation of Materials

International Journal of Aerospace Engineering, 2021
The failure of many aircraft structures and materials is caused by the accumulation of fatigue damage under variable-amplitude cyclic loading wherein the damage evolution of materials is complicated.
Hongsong Li, Yongbao Liu, Xing He, Wangtian Yin   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

FATIGUE LIFE PREDICTION OF METAL MATERIALS BASED ON STRENGTH DEGRADATION

Jixie qiangdu, 2021
In order to study the law of residual strength degradation of metal materials in the process of fatigue,a residual strength degradation model is established based on the definition of fatigue damage.
LIU SuChao, JIANG ChangJie, LIU XinTian
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A fatigue life approach model of automotive parts based on stress equivalence relation

Journal of Highway and Transportation Research and Development
Fatigue failure under alternating loads represents a significant failure mode for automotive components. This study focuses on predicting the fatigue life of automotive parts subjected to multi-level stress loading. Current nonlinear models often require
Xuewen Zhang, Wei Zhou, Lu Zhang
doaj   +1 more source

Impact of Train-Induced Vibration on Railway Cable-Stayed Bridges Fatigue Evaluation

The Baltic Journal of Road and Bridge Engineering, 2016
Under repetitive heavy train traffic, railway steel truss bridges tend to have many fatigue related performance issues, especially at welded joints. Accurate estimation of the stress history at critical locations of welded joints under vehicle loading is
Shiling Pei, Yongle Li, Yulong Bao, Xin Li, Shizhong Qiang   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source