Results 181 to 190 of about 223,388 (402)

Preventing Upper Extremity Cumulative Trauma Disorders [PDF]

, 1998
Thomas F. Fisher
openalex   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

Advanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren, Xiaotong Xu, Zheng Dong, Jiahuang Qiu, Qing'e Shan, Rui Chen, Yajun Liu, Juan Ma, Sijin Liu   +8 more
wiley   +1 more source

Long Term Effects of Chronic Variable Stress Administered during Different Developmental Stages in Mice [PDF]

, 2011
A number of studies have suggested that the occurrence of past trauma can increase an individual\u27s chance of developing PTSD from a new traumatic experience later in life.
Boeh, Henry
core   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

The effect of complex posttraumatic stress and poverty on quality of life among adult survivors of childhood institutional maltreatment: evidence from survivors of the ‘Hyeongje Welfare Institution’ in South Korea

European Journal of Psychotraumatology
Background: Childhood institutional maltreatment (IM) is associated with both complex posttraumatic stress disorder (CTPSD) and poverty in adulthood life, each of which may impact an individual’s quality of life (QoL).
Jae-Woong Kim, Chan Seob Nam, Hyunjung Choi   +2 more
doaj   +1 more source

Traumatic experiences and life events in people with \ud intellectual disability [PDF]

, 2008
Purpose of review \ud The aim of this article is to present and critically evaluate recent research on life events and traumatic experiences as predictors of psychopathology in people with intellectual \ud disability. \ud \ud Recent findings \ud The area
Martorell, Almudena, Tsakanikos, Elias
core  

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

The Effect of Chronic Stress on Generalization of Conditioned Fear [PDF]

, 2016
Prior lifetime experience of stress is a significant risk factor for posttraumatic stress disorder (PTSD) and other anxiety disorders. The mechanisms by which stress conveys these effects are unknown and likely involve complicated neurobiological ...
Senatore, Amanda J
core   +1 more source

Study of Effectiveness of Human Factors Engineering Interference in Cumulative Trauma Disorders Rate Decreasing in the Tehran South Health Center 2005-2006 [PDF]

, 2012
Mohammad Noorisepehr, Jamshid Rahimi, M.B. Delkhosh, A. Kabolizadeh, Rostam Golmohammadi   +4 more
openalex   +1 more source