Results 191 to 200 of about 24,509 (302)

Psychological outcomes in paediatric major trauma patients who require invasive management: protocol for a systematic review and meta-analysis. [PDF]

BMJ Open
Hibberd O, Thomas CE, Gentle S, Angus S, Karageorgos S, Phillips V, Thomas SH.   +6 more
europepmc   +1 more source

Efficacy of Implementing an Ergonomics Program in an Industrial Setting Regarding Cumulative Trauma Disorders to the Upper Extremity

, 1994
Christa Abraham, Lisa H. Evans, Patrick Hoban   +2 more
openalex   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

The mediating role of resilience in the association between trauma type and CPTSD among Swiss older adults. [PDF]

Eur J Psychotraumatol
Thoma MV, Redican E, Shevlin M, Adank N, Maercker A, Rohner SL.   +5 more
europepmc   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Clinical phenotypes of psychosis and reoffending risk among justice-involved adolescents: a population-based cohort study. [PDF]

Front Psychiatry
Akpanekpo EI, Butler T.
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

A comparative analysis of age of onset and associated factors in non-refugee immigrants versus native-born individuals with psychotic disorders. [PDF]

Eur J Psychotraumatol
Trabsa A, Solanes A, Hogg B, Valiente A, Mané A, Pérez-Sola V, Amann BL, Moreno-Alcázar A.   +7 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

The prevalence of potentially traumatic events in childhood and associations with mental disorders, suicide and physical health in adulthood: An Australian nationally representative cross-sectional study. [PDF]

Aust N Z J Psychiatry
Barrett EL, Grummitt L, Jones S, Rowlinson K, Vasilopoulos F, Teesson M, Mills KL, Sunderland M.   +7 more
europepmc   +1 more source