Results 201 to 210 of about 166,028 (379)
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui+17 more
wiley +1 more source
The effect of childhood trauma on bipolar depression. [PDF]
Guillen-Burgos HF+7 more
europepmc +1 more source
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu+13 more
wiley +1 more source
A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology. [PDF]
Huang YH+14 more
europepmc +1 more source
Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang+9 more
wiley +1 more source
Risk Factors for Chronic Pain in Women: The Role of Violence Exposure in a Case-Control Study. [PDF]
Uvelli A, Pugliese E, Ferretti F.
europepmc +1 more source
The effect of cumulative trauma and polarised thinking on severity of depressive disorder
Marta Salla+4 more
openalex +1 more source