Results 301 to 310 of about 223,388 (402)

Placental RTN3L‐dependent ER‐Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress

open access: yesAdvanced Science, EarlyView.
Gestational environmental stress activates ER‐phagy by increasing placental Rtn3l mRNA N6‐methyladenosine modification, further inhibiting placental estradiol synthesis and contributing to fetal testicular dysplasia. This study demonstrates the early prevention and treatment of adult male infertility from the perspective of fetal‐derived diseases ...
Ye‐Xin Luo   +17 more
wiley   +1 more source

A network analysis of ICD-11 complex PTSD symptoms in the treatment-seeking population in Iran. [PDF]

open access: yesBMC Psychiatry
Mohammadi Z   +5 more
europepmc   +1 more source

Engineered Stem Cell Clusters for Extracellular Vesicles‐Mediated Gene Delivery to Rejuvenate Chondrocytes and Facilitate Chondrogenesis in Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
BMSCmotif+miR874/MS system is designed as a gene delivery platform utilizing engineered bone marrow mesenchymal stem cell (BMSC)‐derived extracellular vesicles (EVs) for intercellular communication to achieve sustained delivery of miRNA‐874‐3p. Rejuvenation of chondrocytes and promotion of chondrogenesis are achieved by inhibition of the NF‐κB pathway,
Yuezhou Wu   +7 more
wiley   +1 more source

Pushing the Frontiers: Artificial Intelligence (AI)‐Guided Programmable Concepts in Binary Self‐Assembly of Colloidal Nanoparticles

open access: yesAdvanced Science, EarlyView.
Colloidal nanoparticles self‐assembly advances towards intelligent, customized assembly through precise control of binary co‐assemblies. This review explores the evolution from monolithic to binary assemblies, highlighting how the AI‐guided programmable assembly approach has the potential to shift from passive assembly to active intelligent design.
Cancan Li   +5 more
wiley   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

open access: yesAdvanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang   +11 more
wiley   +1 more source

Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex

open access: yesAdvanced Science, EarlyView.
Cu2Ir NPs based on a Cu‐porphyrin core and cyclometalated Ir(III) substituents achieve combined endogenous peroxynitrite‐triggered NIR chemiluminescence imaging, PTT and PDT for successfully achieving safe thrombolysis, antioxidant and anti‐inflammatory multifunctionality in one single molecule.
Ziwei Wang   +13 more
wiley   +1 more source

The role of prenatal stress and maternal trauma responses in predicting children's mental health during war. [PDF]

open access: yesEur J Psychotraumatol
Yirmiya K   +5 more
europepmc   +1 more source

Flexible Regulation of Optical Properties Based on Structure Size‐Driven Intermolecular Interactions for Phototherapy

open access: yesAdvanced Science, EarlyView.
Herein, ACQ@AIE bimolecular systems are developed by noncovalently combining an aggregated‐caused quenching (ACQ) molecule with three aggregated‐induced emission (AIE) molecules. Differentials in structural size drive different patterns of intermolecular interactions, leading to distinct and tunable optical properties.
Zhichao Gong   +8 more
wiley   +1 more source

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