Results 31 to 40 of about 82,554 (326)

Developmental predictors of young adult borderline personality disorder: a prospective, longitudinal study of females with and without childhood ADHD

BMC Psychiatry, 2023
Background Research on the precursors of borderline personality disorder (BPD) reveals numerous child and adolescent risk factors, with impulsivity and trauma among the most salient. Yet few prospective longitudinal studies have examined pathways to BPD,
Sinclaire M. O’Grady, Stephen P. Hinshaw   +1 more
doaj   +1 more source

A meta-analysis of risk factors for combat-related PTSD among military personnel and veterans. [PDF]

PLoS ONE, 2015
Post-traumatic stress disorder (PTSD), a complex and chronic disorder caused by exposure to a traumatic event, is a common psychological result of current military operations.
Chen Xue, Yang Ge, Bihan Tang, Yuan Liu, Peng Kang, Meng Wang, Lulu Zhang   +6 more
doaj   +1 more source

Exploring the Intersections of Trauma, Structural Adversity, and Psychosis among a Primarily African-American Sample: A Mixed-Methods Analysis

Frontiers in Psychiatry, 2017
Traumatic life events (TLEs) have been associated with multiple psychiatric diagnoses, including anxiety disorders, major depression, PTSD, and psychosis.
Cherise Rosen, Nev Jones, Eleanor Longden, Kayla A. Chase, Mona Shattell, Jennifer K. Melbourne, Sarah K. Keedy, Rajiv P. Sharma, Rajiv P. Sharma   +8 more
doaj   +1 more source

Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

Epigenetics, 2023
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders ...
Seyma Katrinli, Alicia K Smith, Stacy S. Drury, Jonathan Covault, Julian D. Ford, Vijender Singh, Bo Reese, Amy Johnson, Victoria Scranton, Pamela Fall, Margaret Briggs-Gowan, Damion J Grasso   +11 more
doaj   +1 more source

Childhood trauma among adult patients with mental illness in south-western Uganda: A hospital-based study

SSM - Mental Health, 2023
Introduction: Childhood trauma plays a central role in the long-term outcomes and quality of life of adults with mental disorders. Its burden among patients receiving mental health care in rural health facilities has not been established formally.
Bives Mutume Nzanzu Vivalya, Benedict Akimana, Scholastic Ashaba   +2 more
doaj  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

The relationship between trauma, shame, and guilt: findings from a community-based study of refugee minors in Germany [PDF]

European Journal of Psychotraumatology, 2015
Background: The relationships between traumatic stress and self-conscious emotions, such as shame and guilt, remain to be fully explored, especially in refugees, who frequently are exposed to a multitude of stressors.
Sabrina J. Stotz, Thomas Elbert, Veronika Müller, Maggie Schauer   +3 more
doaj   +1 more source

Trauma-related guilt as a mediator between post-traumatic stress disorder and suicidal ideation

Frontiers in Psychiatry, 2023
BackgroundAs a mental health issue, suicide is a growing global concern, with patients who have post-traumatic stress disorder (PTSD) being at particularly high risk.
Po-Han Chou, Po-Han Chou, Shao-Cheng Wang, Shao-Cheng Wang, Shao-Cheng Wang, Shao-Cheng Wang, Chi-Shin Wu, Chi-Shin Wu, Masaya Ito   +8 more
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source