Results 61 to 70 of about 166,028 (379)

Influence of Multiple Traumatic Event Types on Mental Health Outcomes: Does Count Matter? [PDF]

, 2018
The experience of potentially traumatizing events (PTEs) may be associated with conflicting outcomes: individuals may experience greater psychological distress (dose-response theory), or individuals may become more resilient against repeated PTEs (stress-
Brown, Lily A, Contractor, Ateka A, Dranger, Paula, Frankfurt, Sheila B, Gerber, Monica M, Oudshoorn, Kelsey   +5 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

An analysis of the Research Fellowship Scheme of the Royal College of Surgeons of England.

, 2005
BACKGROUND: The Research Fellowship Scheme of the Royal College of Surgeons of England commenced in 1993 with the aim of exposing selected surgical trainees to research techniques and methodology, with the hope of having an impact on surgical research ...
Browne, John P, Coomer, Martyn, Emberton, Mark, Morris, Peter J, Mundy, Anthony R, Nuttall, Martin C, van der Meulen, Jan HP   +6 more
core   +1 more source

Personal risk factors for carpal tunnel syndrome in female visual display unit workers

International Journal of Occupational Medicine and Environmental Health, 2016
Objectives: Carpal tunnel syndrome (CTS) is the most common nerve entrapment syndrome, which since the beginning of the seventies has been linked to the keyboard and visual display unit (VDU). The objective of this study was to investigate the prevalence
Matteo Riccò, Silvia Cattani, Carlo Signorelli   +2 more
doaj   +1 more source

The relationship between trauma, shame, and guilt: findings from a community-based study of refugee minors in Germany [PDF]

European Journal of Psychotraumatology, 2015
Background: The relationships between traumatic stress and self-conscious emotions, such as shame and guilt, remain to be fully explored, especially in refugees, who frequently are exposed to a multitude of stressors.
Sabrina J. Stotz, Thomas Elbert, Veronika Müller, Maggie Schauer   +3 more
doaj   +1 more source

Cancer related PTSD symptoms in patients of all ages and their relatives, and general risk factors [PDF]

, 2017
Since the DSM-IV, a life threatening disease is considered as a potential source of PTSD. One of the core elements of the diagnosis is experiencing a traumatic event or being a witness of a close person experiencing it.
Paleczna, Monika
core   +3 more sources

Hitting the wall: The impact of barriers to care and cumulative trauma exposure on PTSD among Northern Ireland Veterans

Journal of Military Veteran and Family Health
LAY SUMMARY The Northern Ireland (NI) population has high rates of trauma exposure and posttraumatic stress disorder (PTSD) but many barriers prevent people from seeking help/care, which can worsen mental health conditions.
E. Spikol, C. Hitch, M. Robinson, E. McGlinchey, C. Armour   +4 more
semanticscholar   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source