Results 121 to 130 of about 213,098 (343)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Sensitivity of precipitation over China to different cumulus parameterization schemes in RegCM4

Journal of Meteorological Research, 2015
The effect of different cumulus parameterization schemes (CPSs) on precipitation over China is investigated by using the International Centre for Theoretical Physics (ICTP) Regional Climate Model version 4.3 (RegCM-4.3) coupled with the land surface ...
Shaobo Zhang, S. Lü, Y. Bao, D. Ma
semanticscholar   +1 more source

Giant Magnetostriction in Ferrimagnetic SmFe5As3

Angewandte Chemie International Edition, EarlyView.
SmFe5As3 is a newly discovered ferrimagnetic material that displays peculiar volumetric effects as a function of temperature. As a result of two magnetic sublattices—one with d$d$‐electrons of Fe and another with f$f$‐electrons of Sm—single crystals of SmFe5As3 show negative (blue), positive (pink), and zero (beige) thermal expansion along the [010 ...
Oksana Karychort, Jan Priessnitz, Volodymyr Buturlim, Mitja Krnel, Iñigo Robredo, Nazar Zaremba, Ulrich Burkhardt, Helge Rosner, Andrew Fitch, Markus König, Fabrice Wilhelm, Olha Zhak, Dileep Krishnan, Ivan Soldatov, Rudolf Schäfer, Maia Vergniory, Libor Šmejkal, Theo Siegrist, Berit H. Goodge, Krzysztof Gofryk, Yurii Prots, Eteri Svanidze   +21 more
wiley   +1 more source

Metalens‐Enabled Twisted Chromatic Dispersion

Advanced Physics Research, EarlyView.
We successfully demonstrate visible broadband twisted dispersion metalenses. As a proof of concept, we realized two distinct devices: the conical helical and the spring‐like dispersion‐controlled metalenses. These results rigorously validate the universality of our approach in customizing arbitrary continuous 3D dispersion trajectories, thereby ...
Shiyu Zheng, Boyan Fu, Hong Zhang, Shuming Wang   +3 more
wiley   +1 more source

Sensitivity Assessment of WRF Parameterizations over Europe

Proceedings, 2017
Evaluation of the performance of the parameterization schemes used in the WRF model is assessed for temperature and precipitation over Europe at 36 km by 36 km grid resolution using gridded data from the ECA & D 0.25° regular grid.
Ioannis Stergiou, Efthimios Tagaris, Rafaella-Eleni P. Sotiropoulou   +2 more
doaj   +1 more source

Morphological variation in atlas and axis of Neotropical spiny rats (Rodentia, Echimyidae)

The Anatomical Record, EarlyView.
Abstract The unique morphologies of the first two cervical vertebrae, the atlas and axis, represent a significant innovation in mammalian evolution. These structures support the weight of the head and enable intricate movements of the head and neck.
Thomas Furtado da Silva Netto, João Felipe Leal Kaiuca, Adriana Itatí Olivares, William Corrêa Tavares   +3 more
wiley   +1 more source

Improvement in the Modeled Representation of North American Monsoon Precipitation Using a Modified Kain–Fritsch Convective Parameterization Scheme

Atmosphere, 2018
A commonly noted problem in the simulation of warm season convection in the North American monsoon region has been the inability of atmospheric models at the meso-β scales (10 s to 100 s of kilometers) to simulate organized convection, principally ...
Thang M. Luong, Christopher L. Castro, Truong M. Nguyen, William W. Cassell, Hsin-I Chang   +4 more
doaj   +1 more source

Comparison of 30 day integrations with and without interactive clouds [PDF]

A cloud radiation interaction parameterization package has recently been incorporated into a global spectral General Circulation Model (GCM) used for extended range prediction studies at GFDL. The elements of this package are summarized.
Gordon, C. T.
core   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Evaluation of 2 1-D cloud models for the analysis of VAS soundings [PDF]

Evaluation of the satellite Visual Infrared Spin Scan Radiometer Atmospheric Sounder (VISSR) has begun to document several of its critical shortcomings as far as numerical cloud models are concerned: excessive smoothing of thermal inversions; imprecise ...
Emmitt, G. D.
core   +1 more source