Results 171 to 180 of about 5,728 (215)

Microbial Biotransformation of Retinoic Acid by Cunninghamella echinulata and Cunninghamella blakesleeana

Pharmaceutical Research, 1990
Vitamin A (retinol) is needed by higher animals for the maintenance of normal epithelium and growth, and retinoic acid (I) has been proposed to be the active metabolite. Microbial models are useful for the study of mammalian metabolism of xenobiotics. Two species of the fungal genus Cunninghamella afforded products of greater polarity than 1 when fed 1
D A, Hartman, J B, Basil, L W, Robertson, R W, Curley   +3 more
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Cunninghamella bertholletiae

Southern Medical Journal, 1990
Cunninghamella bertholletiae shares many of the features typical of the other agents causing zygomycoses. Those who are immunocompromised constitute the major patient population at risk; the agents as a group are aggressive, the disease is often disseminated, and the pathologic picture of vascular invasion and tissue infarction is common.
B E, Robinson, M T, Stark, T L, Pope, F M, Stewart, G R, Donowitz   +4 more
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Cyhalothrin biodegradation in Cunninghamella elegans

Environmental Science and Pollution Research, 2018
The insecticide λ-cyhalothrin was incubated with planktonic and biofilm cultures of the fungus Cunninghamella elegans. 19F nuclear magnetic resonance spectroscopy demonstrated that the compound was initially biosorbed to the biomass and more slowly degraded by the fungus. Furthermore, the presence of trifluoromethyl-containing metabolites was observed.
William Palmer-Brown, Paula Letícia de Melo Souza, Cormac D. Murphy   +2 more
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Aggressive Cunninghamella Pneumonia in an Adolescent

Journal of Pediatric Hematology/Oncology, 2014
Children with hematologic malignancies may be challenged with life-threatening, invasive fungal infections by organisms that would otherwise have a low potential for virulence in healthy hosts. Presented is a case of a 15-year-old adolescent with B-cell acute lymphoblastic leukemia who was receiving steroids and chemotherapy.
Alpin D, Malkan, Fazal N, Wahid, Bhaskar N, Rao, John A, Sandoval   +3 more
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Biotransformation of Doxepin by Cunninghamella elegans

Drug Metabolism and Disposition, 1999
A filamentous fungus, Cunninghamella elegans ATCC 9245, was used as a microbial model of mammalian metabolism to biotransform doxepin, a tricyclic antidepressant drug. Doxepin is produced as an 85:15% mixture of the trans- (E) and cis- (Z) forms. After 96 h of incubation in Sabouraud dextrose broth, 28% of the drug was metabolized to 16 metabolites. No
J D, Moody, J P, Freeman, C E, Cerniglia
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Recent Advances in Biotransformation by Cunninghamella Species

Current Drug Metabolism, 2021
: The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds.
Manoela Daiele, Gonçalves, Fernanda, Tomiotto-Pellissier, Ricardo Luís Nascimento, de Matos, João Paulo, Assolini, Bruna Taciane, da Silva Bortoleti, Virginia Marcia, Concato, Taylon Felipe, Silva, Janice Aparecida, Rafael, Wander Rogério, Pavanelli, Ivete, Conchon-Costa, Nilton Syogo, Arakawa   +10 more
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Biotransformation of Mirtazapine by Cunninghamella Elegans

Drug Metabolism and Disposition, 2002
The fungus Cunninghamella elegans was used as a microbial model of mammalian metabolism to biotransform the tetracyclic antidepressant drug mirtazapine, which is manufactured as a racemic mixture of R(-)- and S(+)-enantiomers. In 168 h, C. elegans transformed 91% of the drug into the following seven metabolites: 8-hydroxymirtazapine, N-desmethyl-8 ...
Joanna D, Moody, James P, Freeman, Peter P, Fu, Carl E, Cerniglia   +3 more
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Propranolol Metabolism byCunninghamella Bainieri

Xenobiotica, 1989
1. Incubations of racemic propranolol alone or in the presence of either quinidine or sparteine were performed with Cunninghamella bainieri. 2. Five mammalian metabolites of propranolol (4-hydroxypropranolol, desisopropyl-propranolol, 1-naphthoxylactic acid, propranolol glycol and 1-naphthoxyacetic acid) were present in unhydrolysed extracts of the ...
B C, Foster, H S, Buttar, S A, Qureshi, I J, McGilveray   +3 more
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Transformation of artemisinin by Cunninghamella elegans

Applied Microbiology and Biotechnology, 2004
Semi-synthetic derivatives of the anti-malarial drug artemisinin hold great promise in the search for an effective and economical treatment of chloroquine-resistant forms of malaria. Unfortunately, synthetic functionalization of the artemisinin skeleton is often tedious and/or impractical.
Parshikov, Igor A., Muraleedharan, K. M., Avery, Mitchell A., Williamson, John S.   +3 more
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Cunninghamella Infections: Review and Report of Two Cases of Cunninghamella Pneumonia in Immunocompromised Children

Clinical Infectious Diseases, 1993
Infections caused by Cunninghamella bertholletiae are being identified with increasing frequency in immunocompromised patients. We have treated two children with cancer for pulmonary infections caused by this rare fungus. Cunninghamella infection is found in a variety of populations of patients, including both children and adults undergoing ...
A, Cohen-Abbo, P M, Bozeman, C C, Patrick   +2 more
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