Results 41 to 50 of about 3,128 (245)
Artificial Intelligence in the Life SciencesPROTACs are a promising therapeutic modality that harnesses the cell’s built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs is challenging and requires significant domain expertise, time, and cost ...
Stefano Ribes +3 more
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BMC Bioinformatics, 2011 Background We address the goal of curating observations from published experiments in a generalizable form; reasoning over these observations to generate interpretations and then querying this interpreted knowledge to supply the supporting evidence.
Bota Mihail +4 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Medical multimodal multitask foundation model for lung cancer screening
Nature CommunicationsLung cancer screening (LCS) reduces mortality and involves vast multimodal data such as text, tables, and images. Fully mining such big data requires multitasking; otherwise, occult but important features may be overlooked, adversely affecting clinical ...
Chuang Niu +8 more
doaj +1 more source
MoMA A&D talks: on curating architecture and design
Risco Revista de Pesquisa em Arquitetura e Urbanismo (Online), 2018 .
Luis Michael, Amanda Saba Ruggiero
openaire +2 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
HeritageBackground: This research explores the intersection between cultural heritage and mental health, analyzing how heritage mediation acts as a strategic asset in the personal recovery of individuals experiencing mental distress. Methods: A systematic review
Alejandra López Mera +2 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Curatorial Practice as Production of Visual and Spatial Knowledge: Panelists Respond
Contemporaneity: Historical Presence in Visual Culture, 2015 Three participants in the panel “Curatorial Practice as Production of Visual and Spatial Knowledge” reflect upon the ideas raised in their discussion about curating, both in their respective fields and as a general practice.
Alison Langmead +2 more
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