Results 191 to 200 of about 569,836 (364)

Do Cure Violence Programs Reduce Gun Violence? Evidence from New York City [PDF]

open access: yesarXiv
Cure Violence is a community violence intervention program that aims to reduce gun violence by mediating conflicts, "treating" high-risk individuals, and changing community norms. Using NYC shootings data from 2006-2023, we assess the efficacy of Cure Violence using both difference-in-differences and event study models.
arxiv  

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

A general approach to fitting multistate cure models based on an extended-long-format data structure [PDF]

open access: yesarXiv
A multistate cure model is a statistical framework used to analyze and represent the transitions individuals undergo between different states over time, accounting for the possibility of being cured by initial treatment. This model is particularly useful in pediatric oncology where a proportion of the patient population achieves cure through treatment ...
arxiv  

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