Results 91 to 100 of about 112,173 (343)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Compressive strength prediction of fly ash/slag-based geopolymer concrete using EBA-optimised chemistry-informed interpretable deep learning model

Developments in the Built Environment
Geopolymer concrete (GPC) is a sustainable alternative to conventional Portland cement concrete, utilising industrial by-products like fly ash (FA) and ground-granulated blast-furnace slag (GGBS). However, optimising GPC's compressive strength (CS) often
Yang Yu, Iman Munadhil Abbas Al-Damad, Stephen Foster, Ali Akbar Nezhad, Ailar Hajimohammadi   +4 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Characteristics and preliminary healing ability of polydimethylsiloxane elastomers

Journal of Materials Research and Technology
Flexible polydimethylsiloxane (PDMS)-based elastomers are extensively used in microfluidics and microelectronics due to their exceptional thermal stability, chemical inertness, flexibility, and stretchability.
Thi Sinh Vo, Truong Sinh Nguyen, Byounghyun Jeon, Tran Thi Bich Chau Vo, Soobean Han, Seung-Hyun Lee, Kyunghoon Kim   +6 more
doaj   +1 more source

Simulation of expansion in cement based materials subjected to external sulfate attack

Ain Shams Engineering Journal, 2014
The standard test for length change in hydraulic-cement mortars exposed to sulfate solution, ASTM C1012-95, has been widely used by researchers to study the sulfate resistance of cement based materials. However, there are deficiencies in this test method
O.A. Hodhod, G. Salama
doaj   +1 more source

Poly(acrylonitrile-co-butadiene) as polymeric crosslinking accelerator for sulphur network formation

Heliyon, 2020
The major controlling factors that determine the various mechanical properties of an elastomer system are type of chemical crosslinking and crosslink density of the polymer network.
Sakrit Hait, Juan López Valentín, Antonio González Jiménez, Pilar Bernal Ortega, Anik Kumar Ghosh, Klaus Werner Stöckelhuber, Sven Wießner, Gert Heinrich, Amit Das   +8 more
doaj   +1 more source

Environmentally Friendly Pervious Concrete for Treating Deicer-Laden Stormwater: Phase II [PDF]

, 2018
In Phase I of this project, graphene oxide (GO)-modified pervious concrete was developed using coal fly ash as the sole binder. The primary objectives of Phase II of this project were (1) to evaluate the stormwater infiltration capacity of GO-modified ...
Shi, Xianming, Xu, Gang
core  

Mechanical characterization of sol–gel epoxy-silylatedhyperbranched poly(ethyleneimine) coatings by meansof Depth Sensing Indentation methods [PDF]

, 2016
A series of hybrid epoxy-silica coatings were prepared from a synthesized hyperbranched poly(ethyleneimine) with ethoxysilyl groups at the chain ends and diglycidylether of bisphenol A in different proportions.
Acebo Gorostiza, Cristina, Ramis Juan, Xavier, Serra Albet, Maria Àngels, Vicente, Lorenzo   +3 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source