Results 101 to 110 of about 109,294 (342)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Low-cost optical manipulation using hanging droplets of PDMS [PDF]

, 2015
We propose and demonstrate a low-cost optical micromanipulation system that makes use of simple microfrabricated components coupled to a smartphone camera for imaging. Layering hanging droplets of polydimethylsiloxane (PDMS) on microscope coverslips, and
Ashkin, Baden, Bellina, Breslauer, Budde, Burnham, Chowdhury, Erickson, Fei, Gambin, Hofmann, Jeong, Lee, Mao, Pralle, Ren, Skandarajah, Smith, Svoboda, Tadmor, Wilbur   +20 more
core   +3 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Poly(acrylonitrile-co-butadiene) as polymeric crosslinking accelerator for sulphur network formation

Heliyon, 2020
The major controlling factors that determine the various mechanical properties of an elastomer system are type of chemical crosslinking and crosslink density of the polymer network.
Sakrit Hait, Juan López Valentín, Antonio González Jiménez, Pilar Bernal Ortega, Anik Kumar Ghosh, Klaus Werner Stöckelhuber, Sven Wießner, Gert Heinrich, Amit Das   +8 more
doaj   +1 more source

Influences of chloride immersion on zeta potential and chloride in concentration of cement-based materials [PDF]

, 2015
In this paper, the zeta potential of freshly mixed cement paste and hardened cement pastes, as well as the concentration index, was measured. The influences of chloride concentration in mixing water and slag content on zeta potential of freshly mixed ...
De Schutter, Geert, Hu, Xiang, Shi, Caijun   +2 more
core  

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Biopolymer stabilization of clayey soil

Journal of Rock Mechanics and Geotechnical Engineering
This study investigates the efficacy of sodium alginate (SA), xanthan gum (XG), guar gum (GG) and chitosan (CS) — each applied at five different solid biopolymer-to-water mass ratios (or dosages) and cured for 7 d and 28 d — on the unconfined compressive
Mahdieh Azimi, Amin Soltani, Mehdi Mirzababaei, Mark B. Jaksa, Nanjappa Ashwath   +4 more
doaj   +1 more source

Designed-in molecular interactions lead to superior thermo-mechanical properties in nanocomposites [PDF]

, 2011
The effect of the nanofiller chemistry on the mechanical behaviour of thermoset polymer matrix nanocomposites is investigated. The interaction between a crosslinked polymer resin and the reinforcing nanofibers driven by their chemistry is revealed by ...
Atılgan, Ali Rana, Atilgan, Ali Rana, Atılgan, Canan, Atilgan, Canan, Bilge, Kaan, Menceloglu, Yusuf Z., Menceloğlu, Yusuf Z., Ozden Yenigun, Elif, Papila, Melih, Özden Yenigün, Elif   +9 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Physicochemical Properties of Alkali-Activated Ground-Granulated Blast Furnace Slag (GGBS)/High-Calcium Fly Ash (HCFA) Cementitious Composites

Buildings
This study advances alkali-activated cementitious materials (AACMs) by developing a ground-granulated blast furnace slag/high-calcium fly ash (GGBS/HCFA) composite that incorporates Tuokexun desert sand and by establishing a clear linkage between ...
Yi Si, Hong Wu, Runtao La, Bo Yang, Ting Liu, Yong Huang, Ming Zhou, Meng Li   +7 more
doaj   +1 more source