Results 101 to 110 of about 8,613 (249)

Multifunctional Fluorescent Probe for Simultaneous Detection of ATP, Cys, Hcy, and GSH: Advancing Insights into Epilepsy and Liver Injury

Advanced Science
Adenosine triphosphate (ATP) is a critical intracellular energy currency that plays a key role in various cellular processes and is closely associated with numerous diseases.
Ting Yu, Yang Li, Jing Li, Yabing Gan, Zhengze Long, Yun Deng, Youyu Zhang, Haitao Li, Peng Yin, Shouzhuo Yao   +9 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

An interpretable model for large-scale smart contract vulnerability detection

Blockchain: Research and Applications
Smart contracts hold billions of dollars in digital currency, and their security vulnerabilities have drawn a lot of attention in recent years. Traditional methods for detecting smart contract vulnerabilities rely primarily on symbol execution, which ...
Xia Feng, Haiyang Liu, Liangmin Wang, Huijuan Zhu, Victor S. Sheng   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Beyond the p < 0.05 trap: the adaptive integrity model for preventing and detecting P-hacking

Frontiers in Education
When statistical significance becomes the currency of publication, the incentive to reach p < 0.05 can subtly shape research behavior. While many researchers report their findings with integrity, others face implicit pressures that increase the ...
Don A. Affognon
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Modern Trends and Recent Applications of Hyperspectral Imaging: A Review

Technologies
Hyperspectral imaging (HSI) is an advanced imaging technique that captures detailed spectral information across multiple fields. This review explores its applications in counterfeit detection, remote sensing, agriculture, medical imaging, cancer ...
Ming-Fang Cheng, Arvind Mukundan, Riya Karmakar, Muhamed Adil Edavana Valappil, Jumana Jouhar, Hsiang-Chen Wang   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Fake Currency Detection using Image Processing (Case Study Libyan Currency)

Journal of Pure & Applied Sciences, 2019
طرق عديدة طورت بغرض تقليص الاعتماد على العملة الورقية كاعتماد البطاقات البلاستيكية المغنطيسية او البطاقة الذكية الا الناس لاتزال تستعمل النقود الورقية في مساحات واسعة من العالم وهذا ما يشجع على تزويرها. فاكتشاف تزوير العملة يعني معالجة لكشف المزورة من تلك العملة وهذا الامر يشكل هاجزا للعديد من الدول حول العالم.
openaire   +1 more source