Results 31 to 40 of about 10,074,268 (294)

Binary Genetic Encoding for the Synthesis of Mixed-Mode Circuit Topologies [PDF]

, 2012
A binary genetic encoding (BGE) representation for the automatic synthesisof mixed-mode circuit topologies, is introduced. First, the genetic encodingof unity-gain cells (UGCs), such as voltage (VF) and current followers (CF), andvoltage (VM) and current
MIGUEL AURELIO DUARTE VILLASEÑOR, LUIS GERARDO DE LA FRAGA, ESTEBAN TLELO CUAUTLE   +2 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single VDGA-Based Mixed-Mode Universal Filter and Dual-Mode Quadrature Oscillator

Sensors, 2022
This article presents the circuit designs for a mixed-mode universal biquadratic filter and a dual-mode quadrature oscillator, both of which use a single voltage differencing gain amplifier (VDGA), one resistor, and two capacitors.
Natchanai Roongmuanpha, Worapong Tangsrirat, Tattaya Pukkalanun   +2 more
doaj   +1 more source

Analogue IC Design The current-mode approach

, 1993
The book covers the following areas: analogue integrated circuit design; current-mode circuit; current conveyor; current-mode analogue amplifier; high frequency CMOS transconductor; bipolar current mirror; dynamic current mirror; continuous-time filter ...
Toumazou, Chris
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Low Voltage High Performance CMOS Current Mode Four-Quadrant Analog Multiplier Circuit [PDF]

Radioengineering, 2022
This paper describes a new CMOS current mode four-quadrant analog multiplier circuit. The proposed design is based on a high performance squarer cell, whose main core is realized by the up–down topology trans-linear loop using flipped voltage followers ...
T. Ettaghzouti, D. Khlaifia, N. Zitouni, N. Hassen   +3 more
doaj  

Simulation and research of battery simulator based on sliding mode control

Dianzi Jishu Yingyong, 2022
Based on the current reversible chopper circuit, the Buck-Boost converter is constructed by sliding mode control method, and a battery simulator with two-way current flow in topological structure is implemented to simulate the charging and discharging ...
Hu Xia, Cao Wenzhang, Dai Yuanyuan
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source