Results 171 to 180 of about 124,676 (264)

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Methylphenidate Treatment and Risk of Psychotic Disorder.

JAMA Psychiatry
Healy C, O'Hare K, Lång U, Metsälä J, Pulakka A, McGrath J, Migone M, Keating D, Romaniuk L, Gyllenberg D, Kajantie E, Perrett G, Hill J, Elwert F, Kelleher I.   +14 more
europepmc   +1 more source

Frailty index predicts the risk of 17 health outcomes in distinct ways: prospective findings from the Moli-sani Study. [PDF]

Age Ageing
Bracone F, Di Castelnuovo A, Costanzo S, Gialluisi A, Bonaccio M, Persichillo M, De Curtis A, Magnacca S, Panzera T, Orlandi S, Cherubini A, Cerletti C, Donati MB, de Gaetano G, Iacoviello L.   +14 more
europepmc   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

The Genetic Origin of Uneven Cognitive Profiles in Heritable Neurodevelopmental Conditions and Individual Differences: Computational Investigations. [PDF]

Dev Sci
Kohli M, Magoulas G, Thomas MSC.
europepmc   +1 more source

Sustainability of India’s Current Account Deficit

Sustainability of India’s Current Account Deficit
The study empirically investigates the long-run sustainability of India’s current account deficit and the factors that have affected its current account balance by applying Husted (1992) intertemporal budget constraint model and Keynesian national account identity, respectively. We utilize a different empirical approach and extend the data set.
openaire  

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source

Final Subcortical Motor Mapping Threshold and Overall Survival After Motor-Eloquent Glioblastoma Resection: Exploratory Analysis of Residual Fluorescence at the Motor Boundary. [PDF]

Cancers (Basel)
Krupa P, Kotek F, Bartos M, Vachek M, Krupova M, Paulikova S, Kasparova P, Cesak T.   +7 more
europepmc   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Animal models for the study of ADHD: the need for next-generation models. [PDF]

Front Psychiatry
Furuie H, Hatakeyama T, Harigai W, Katayama T, Tsuchiya KJ, Takahashi N.   +5 more
europepmc   +1 more source