Results 211 to 220 of about 662,882 (291)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Neural Mechanisms Underlying Reading Impairment in Children Learning a Second Language: A Review. [PDF]

Behav Sci (Basel)
Zhang J, Li B, Li H.
europepmc   +1 more source

Defect Dynamics and Solution‐Processed Interconnects in Perovskite‐Organic Tandem Solar Cells

Advanced Science, EarlyView.
In this study, we identify the underlying cause of efficiency losses in WBG perovskites, which is ascribed to the presence of mobile defects distributed at surface regions. We further employ effective passivation agent with functional chemical groups to facilitate the healing of the mobile defects, thereby enhancing the VOC to 1.35 V and champion ...
Yingjie Hu, Qianyi Li, Kaifeng Jing, Jiangsheng Yu, Fuyi Zhou, Zhenhai Ai, You Chen, Yue Zhao, Yijia Zhang, Zhenyi Ni, Yang Bai, Gang Li, Guang Yang   +12 more
wiley   +1 more source

Deciduous afforestation as a natural climate solution: impacts on biomass and carbon sequestration in boreal forests of Canada. [PDF]

Carbon Balance Manag
du Toit F, Coops NC, Mulverhill C, Toomey A.   +3 more
europepmc   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Integrated insular phenotype (IIP) versus Berger-Sanai and Yasargil classifications: comparative prognostic value in surgery of insular gliomas. [PDF]

Acta Neurochir (Wien)
Kliuchka V.
europepmc   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Who seeks help? Characteristics of doctors accessing mental health support in England: 4-year national review. [PDF]

BJPsych Open
Perera B, Jagtiani M, Dallmeyer L, Courtenay K, Lennard S, Shankar R, Hassiotis A, Al-Najjar Z.   +7 more
europepmc   +1 more source

Enhanced Bandgap Flexibility in Perovskite‐Silicon Tandem Solar Cells via Three‐Terminal Architecture

Advanced Science, EarlyView.
Three‐terminal (3T) perovskite/silicon tandem solar cells overcome the current‐matching constraints of 2T designs. Using an IBC POLO silicon bottom cell, we demonstrate a 30.1% PCE, with performance largely decoupled from perovskite bandgap and enhanced resilience under realistic, time‐dependent solar spectra.
Mohammad Gholipoor, Michael Rienaecker, Xuzheng Liu, Seyedamir Orooji, Lingyi Fang, Paul Fassl, Renjun Guo, Uli Lemmer, Robby Peibst, Ulrich Wilhelm Paetzold   +9 more
wiley   +1 more source

Confirmatory factor analysis of competing PANSS negative symptom models: data from OPTiMiSE first-episode schizophrenia study. [PDF]

BJPsych Open
Demjaha A, Stahl D, Arango C, Glenthøj B, Rodriguez-Jimenez R, Díaz-Caneja CM, Baandrup L, Ebdrup B, Paz Garcia-Portlla M, Diaz-Marsa M, Winter-van Rossum I, Kahn R, Dazzan P, McGuire P.   +13 more
europepmc   +1 more source