Results 121 to 130 of about 1,529,833 (263)

Increasing the Quality Indicators of Current Collection of Electric Locomotives Alternating Current

, 2023
UKR: Розрахунково-пояснювальна записка до кваліфікаційної роботи на здобуття першого рівня вищої освіти (бакалавр) на тему «Підвищення показників якості струмознімання електровозів змінного струму» виконана в обсязі 78 аркушів машинописного тексту з ...
Міхальчук, Микола Миколайович
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Quality of conventional fixed piston samples of Norwegian soft clay

, 2009
It is well accepted that the quality of soft clay samples obtained using standard fixed piston samplers can be relatively poor and that block samples are necessary to yield very high quality samples.
El Hadj, Nouri, Hagberg, Knut, Long, Michael (Michael M.)   +2 more
core   +1 more source

Research on Pantograph-Catenary Dynamics Characteristics in Mixed Double Pantographs Formation of Different Types

Chengshi guidao jiaotong yanjiu
［Objective］ Due to the influence of the leading pantograph in double pantographs operation, the current collection performance of the trailing pantograph often degrades.
LU Wenwei, ZHOU Ning, CHEN Hongming, WANG Xuyang, CHENG Yao, ZHANG Weihua   +5 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mental Health and Its Relationship to Quality of Life among a Sample of Middle School Teachers during the COVID-19 Pandemic

مجلة العلوم و آفاق المعارف
The current study aims to identify the nature of the relationship between mental health and quality of life among a sample of middle school teachers in Laghouat, Algeria, during the COVID-19 pandemic.
djamal. .fattam
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study on Model Reference Adaptive Control for Subway Pantographs

Kongzhi Yu Xinxi Jishu
The coupling performance of subway pantographs with catenaries affects the quality of current collection and the safety of trains. The rigidity of these catenaries exhibits periodicity and fluctuations due to factors such as geographical locations ...
YANG Gang, SHEN Xin, KONG Guowei
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source