Results 241 to 250 of about 331,613 (287)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Theoretical investigation and practical validation of AI based fault detection in BJT amplifier circuits. [PDF]

Sci Rep
Selim KK, Alaa A, Hassan O, Abdellatif SO.   +3 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Exergy, economic, and environmental study for flat plate solar collector using pulsating flow. [PDF]

Sci Rep
Sharafeldin MA, Marzouk SA, Abdelghany MT.   +2 more
europepmc   +1 more source

Opto electronic system for real time health evaluation of photovoltaic panels. [PDF]

Sci Rep
Mas'ud AA, Cuadra I, Ardila-Rey J, Barraza R, Sánchez-Squella A, Montoya OD, AlGarni HZ.   +6 more
europepmc   +1 more source

Breaking the p-type doping barrier in β-Ga₂O₃: a GaN-based heterojunction bipolar transistor with high gain, high breakdown, and RF capability. [PDF]

RSC Adv
Than PH, Than TQ, Takaki Y.
europepmc   +1 more source

Energy, exergy, and environmental performance of a solar dryer for orange slices across tray levels and thicknesses. [PDF]

Sci Rep
Elwakeel AE, Oraiath AAT, Abdurraziq WAM, Székács A, Saeed O, Eid MH, Al-Harbi MS, Ahmed AF, Tantawy AA.   +8 more
europepmc   +1 more source

High-Performance Supercapacitors with Femtosecond-Laser-Nanostructured Current Collectors. [PDF]

ACS Appl Eng Mater
Kuznetsov O, Ivashchyshyn F, Lotnyk A, Braun N, Prager A, Babizhetskyy V, Zayats AV, Gnilitskyi I.   +7 more
europepmc   +1 more source