Results 41 to 50 of about 784,662 (197)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Experimental Test bed to De-Risk the Navy Advanced Development Model [PDF]
, 2017 This paper presents a reduced scale demonstration test-bed at the University of Texas’ Center for Electromechanics (UT-CEM) which is well equipped to support the development and assessment of the anticipated Navy Advanced Development Model (ADM).
Feng, X +6 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
ANALISIS SETTING RELAY DIFERENSIAL PADA TRAFO TENAGA 60 MVA DI GARDU INDUK CIGERELENG 150 kV / 20 kV [PDF]
, 2016 Penelitian ini bertempat di PT.PLN (PERSERO) Transmisi Jawa Bagian Tengah APP Bandung dengan subjek yang diangkat adalah perhitungan setting relay diferensial pada trafo tenaga 60 MVA di Gardu Induk Cigereleng 150 kV / 20 kV.
Aditama, Iqbal Dinoer
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Analisis Kerja Rele Overall Differential Pada Generator Unit I PLTA Ketenger PT Indonesia Power UBP Mrica [PDF]
, 2010 Plant has two important equipment that are the generator and transformer. Therefore, it should be protected well by the overall differential relay. This relay must be reliable from the disturbances that might arise.
Prasetijo, H. (Hari) +1 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Determination of protection system requirements for DC UAV electrical power networks for enhanced capability and survivability [PDF]
, 2011 A growing number of designs of future Unmanned Aerial Vehicle (UAV) applications utilise dc for the primary power distribution method. Such systems typically employ large numbers of power electronic converters as interfaces for novel loads and generators.
Burt, Graeme +3 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source