Results 71 to 80 of about 1,227,308 (328)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Research on optimization strategy of differential protection for inrush current in converter transformer considering magnetic flux restraint

AIP Advances
The converter transformer is a critical component of the HVDC transmission system and its operational stability is essential for the overall safety of the power grid.
Ran Deng, Haotian Kong, Liangchuang Li, Changan Lu, Ao Xu, Chenguang Wang   +5 more
doaj   +1 more source

Development of power system protection based on optical current measurement [PDF]

, 2013
A theoretical evaluation of a novel, all-optical differential current protection scheme employing low voltage piezoelectric transducers, fiber Bragg grating sensors and Rogowski coils is presented in this paper.
Booth, Campbell, Dysko, Adam, Fusiek, Grzegorz, Nasir, Muhammad, Niewczas, Pawel, Orr, Philip   +5 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Reliability of an all-optical differential current detection technique during environmental temperature perturbations [PDF]

, 2014
The reliability of a novel, all-optical differential current protection scheme over varying environmental conditions is investigated in this paper. By monitoring the optical power reflected from two matched hybrid fiber Bragg grating current sensors and ...
Fusiek, Grzegorz, Niewczas, Pawel, Orr, Philip   +2 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Adaptability analysis of differential protection for renewable energy outgoing lines based on current complex plane

Zhejiang dianli
Differential protection is a primary protection scheme commonly deployed for high-voltage AC outgoing lines connecting renewable energy power plants.
YU Su, ZHOU Zexin, WANG Xingguo
doaj   +1 more source

ANALISIS SETTING RELAY DIFERENSIAL PADA TRAFO TENAGA 60 MVA DI GARDU INDUK CIGERELENG 150 kV / 20 kV [PDF]

, 2016
Penelitian ini bertempat di PT.PLN (PERSERO) Transmisi Jawa Bagian Tengah APP Bandung dengan subjek yang diangkat adalah perhitungan setting relay diferensial pada trafo tenaga 60 MVA di Gardu Induk Cigereleng 150 kV / 20 kV.
Aditama, Iqbal Dinoer
core  

Environmental protection and the generalized system of preferences : a legal and appropriate linkage? [PDF]

, 2008
This article will question the legality of measures of environmental ‘conditionality’ in the Generalized System of Preferences [GSP] of the European Community [EC].
Switzer, Stephanie
core   +1 more source