Results 81 to 90 of about 1,227,308 (328)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

FBG-based fibre-optic current sensors for power systems protection : laboratory evaluation [PDF]

, 2009
Conventional differential current unit protection schemes rely on a pair of electronic protection relays that measure current phasors separately at the boundaries of the protected zone.
Booth, Campbell, Dysko, Adam, Niewczas, Pawel, Orr, P.   +3 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Flexible protection architectures using distributed optical sensors [PDF]

, 2012
In this paper we describe recent developments in flexible protection schemes that make use of passive fibre Bragg grating (FBG) based transducers for the distributed measurement of voltage and current.
Beaumont, Phil, Booth, Campbell, Dysko, Adam, Fusiek, Grzegorz, Kawano, Fumio, Niewczas, Pawel, Nishida, Tomonori, Orr, Philip   +7 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research on application of active current differential protection method on AC transmission lines in UHV AC–DC interconnected system

The Journal of Engineering, 2019
The rapid development of ultra-high voltage (UHV) AC–DC interconnected system has brought with it some new features, such as characteristics of distributed parameters becoming more distinct, internal parameters changing faster, and harmonic becoming more
Yangwu Shen, Xiangtian Deng, Lihong Zhang, Jinrui Tang, Jun Ye   +4 more
doaj   +1 more source

Determination of protection system requirements for DC UAV electrical power networks for enhanced capability and survivability [PDF]

, 2011
A growing number of designs of future Unmanned Aerial Vehicle (UAV) applications utilise dc for the primary power distribution method. Such systems typically employ large numbers of power electronic converters as interfaces for novel loads and generators.
Burt, Graeme, Fletcher, Steven, Galloway, Stuart, Norman, Patrick   +3 more
core   +1 more source

Fault current control of MMC in HVDC-connected offshore wind farm: A coordinated perspective with current differential protection

International Journal of Electrical Power & Energy Systems, 2023
Guoqing Gao, Heng Wu, F. Blaabjerg, Xiongfei Wang   +3 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source