Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Out-of-Pocket Expenses in Patients with Psoriasis: A Study from a Tertiary Care Hospital in North India. [PDF]
Indian Dermatol Online JBhandari A +6 more
europepmc +1 more source
Advanced Science, EarlyView.A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao +3 more
wiley +1 more source
Human Epidermal Growth Factor Receptor 2 Quantification Using Computational Pathology to Identify Novel Biomarkers for Trastuzumab Deruxtecan-Treated Human Epidermal Growth Factor Receptor 2-Positive Gastric Cancer. [PDF]
JCO Precis OncolKapil A +20 more
europepmc +1 more source
Advanced Science, EarlyView.Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu +7 more
wiley +1 more source
Huimin Insurance and unequal economic welfare between urban and rural areas: evidence from Chinese cities. [PDF]
Front Public HealthMa J, Li S, Xue W.
europepmc +1 more source
Electrochemical Modulation of Laser‐Induced Covalent Functionalization of Graphene
Advanced Science, EarlyView.Photoelectrochemical functionalization of graphene introduces the electrochemical potential as an additional parameter for the laser‐induced covalent modification of graphene. Tuning of the potential allows for amplification or suppression of the functionalization reaction with constant laser parameters, which enables in situ Raman analysis of ...
Tamara Nagel +7 more
wiley +1 more source
'A New Pace of Life': A Mixed-Methods Exploration of Retirement Plans, Preparations and Experiences in Middle-Aged and Older Autistic and Non-Autistic Adults. [PDF]
AutismKowalczyk Z +4 more
europepmc +1 more source
Wavefront Line‐Scan Imaging Via a Single‐Pixel Detector
Advanced Science, EarlyView.We propose and demonstrate a wavefront line‐scan imaging paradigm that integrates 1D spatial light modulation with single‐pixel detection. Benefiting from 1D modulation, not only is the imaging speed improved, but also the storage of modulation patterns is reduced by several orders of magnitude.
Nuo Liu +4 more
wiley +1 more source