Results 41 to 50 of about 77,391 (263)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The Value of the Liberal Arts and What It Means for Orientation Professionals
Journal of College Orientation, Transition, and Retention, 2002 The university was founded on a tradition of liberal arts education, but in recent years, attention to these fields has diminished. The current study examined the hiring of liberal arts graduates by businesses, in the hopes that orientation professionals
Penny Fripp Jones
doaj +1 more source
Frontiers in Psychology, 2020 There have been recent concerns about an “epidemic of loneliness” during the pandemic, given the pervasiveness of loneliness in the population and its harmful effects on health and well-being.
Sarah E. McComb +3 more
doaj +1 more source
The Fear-Avoidance Model of Musculoskeletal Pain: Current State of Scientific Evidence
Journal of Behavioral Medicine, 2006 Research studies focusing on the fear-avoidance model have expanded considerably since the review by Vlaeyen and Linton (Vlaeyen J. W. S. & Linton, S. J. (2000). Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Pain, 85(3), 317--332).
Leeuw, Maaike +5 more
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Fear-induced bradycardia in mental disorders: Foundations, current advances, future perspectives
Neuroscience & Biobehavioral Reviews, 2023 Fear-induced bradycardia, a transient heart rate deceleration related to a threatening event, is a powerful technique used to assess fear conditioning in humans. During the last century, studies highlighted its usefulness, even when applied to patients with various psychiatric disorders.
Battaglia S., Nazzi C., Thayer J. F.
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Current opinion about surgery-related fear and anxiety
Journal of Perioperative Nursing, 2018 Undergoing a surgical procedure is a major life event for many and can lead to stressors such as heightened fear and associated anxiety. The fear of undergoing surgery or an invasive medical procedure is correctly termed ‘tomophobia’ and lifetime prevalence is estimated at 12.8 per cent.
Nick Ralph, Philip Norris
openaire +3 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source