Results 51 to 60 of about 245,043 (276)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Unequilibrated Charge Carrier Mobility in Organic Semiconductors Measured Using Injection Metal–Insulator–Semiconductor Charge Extraction by Linearly Increasing Voltage

Advanced Photonics Research
The charge carrier mobility in tris(4‐carbazoyl‐9‐ylphenyl)amine (TCTA), a host and hole transport material typically used in organic light‐emitting diodes (OLEDs), is measured using charge carrier electrical injection metal–insulator–semiconductor ...
Mile Gao, Paul L. Burn, Gytis Juška, Almantas Pivrikas   +3 more
doaj   +1 more source

Expert Opinion on Addressing the Gap in Injection Technique and Needle Reuse for People with Diabetes in Indonesia

Diabetes, Metabolic Syndrome and Obesity, 2023
Pradana Soewondo,1 Ketut Suastika,2 Ida Ayu Kshanti,3 Mardianto Mardianto,4 Sony Wibisono Mudjanarko,5 R Bowo Pramono,6 Dyah Erti Mustikawati7 1Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital ...
Soewondo P, Suastika K, Kshanti IA, Mardianto M, Mudjanarko SW, Pramono RB, Mustikawati DE   +6 more
doaj  

Development of Measuring Technique of Start Combustion using Ion Current Measurement in a Controlled Reactivity Engine [PDF]

Research & Knowledge, 2019
This project aims to develop a technique for measuring the start of the combustion. The principle of ion current measurement is used in the controlled reactivity engine combustion.
Nawee Nuntapap, Chaiya R, Ronnachart Munsin, Ob Nilapai   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pilot Study: Hyaluronic Acid Filler Injection Techniques to Achieve Facial Balance in Asian Patients

Plastic and Reconstructive Surgery, Global Open
Background:. Current standard beauty practices in East Asia focus on enhancing and refining Asian features within cultural normalities. Methods:. This pilot study presents injection techniques using hyaluronic acid filler (YVOIRE), focusing on East Asian
Jae Yoon Jung, MD, Jianmei Huang, MD, Yan Wu, MD, Guanhong Zhong, MD, Juan Wang, MD, Jung Im No, MD, Woonji Jang, MD, PhD, Liyao Cong, DDS, PhD   +7 more
doaj   +1 more source

Robust spin-current injection in lateral spin valves with two-terminal Co2FeSi spin injectors

AIP Advances, 2017
We demonstrate generation and detection of pure spin currents by combining a two-terminal spin-injection technique and Co2FeSi (CFS) spin injectors in lateral spin valves (LSVs).
S. Oki, T. Kurokawa, S. Honda, S. Yamada, T. Kanashima, H. Itoh, K. Hamaya   +6 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Closed-Loop Intravenous Drug Administration Using Photoplethysmography

IEEE Journal of Translational Engineering in Health and Medicine, 2018
An optically-based injection control system has been developed for preclinical use for an intravenous drug delivery application. Current clinical drug delivery for oncology typically provides for intravenous administration without an awareness of ...
George W. Carpenter, Holly G. Myers, Eric A. Sherer, Katie A. Evans, D. Patrick O'Neal   +4 more
doaj   +1 more source