Results 201 to 210 of about 19,714,201 (367)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Toward in vivo bronchoscopic functional CFTR assessment using a short circuit current measurement probe. [PDF]

Am J Physiol Lung Cell Mol Physiol
Otuya DO, Liu Z, Joseph R, Hanafy MA, Vijaykumar K, Stanford D, Raju SV, Baker EH, Rowe SM, Tearney GJ, Solomon GM.   +10 more
europepmc   +1 more source

Measurements of Best, Worst, and Average Socket Comfort Are More Reliable Than Current Socket Comfort in Established Lower Limb Prosthesis Users

, 2021
Sara J. Morgan, Robert L. Askew, Brian J. Hafner   +2 more
openalex   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

High-Precision Tunneling Magnetoresistance (TMR) Current Sensor for Weak Current Measurement in Smart Grid Applications. [PDF]

Micromachines (Basel)
Xu Y, Jin Z, Chen J.
europepmc   +1 more source

Current Measurement Transducer Based on Current-to-Voltage-to-Frequency Converting Ring Oscillator with Cascade Bias Circuit. [PDF]

Sensors (Basel), 2020
Park J, Park JH, Jung SO.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Eddy Current Measurement of Electrical Resistivity in Heat-Treated Zr-2.5%Nb Pressure Tubes. [PDF]

Sensors (Basel)
Thorpe WG, Underhill PR, Krause TW.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Conductive Atomic Force Microscopy-Ultralow-Current Measurement Systems for Nanoscale Imaging of a Surface's Electrical Properties. [PDF]

Sensors (Basel)
Sikora A, Gajewski K, Badura D, Pruchnik B, Piasecki T, Raczkowski K, Gotszalk T.   +6 more
europepmc   +1 more source