Results 51 to 60 of about 929,929 (317)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
INVESTIGATION OF MICROPROCESSOR TRANSFORMER CURRENT PROTECTION IN SHORT CIRCUIT FAULT MODES
Наука и техника, 2014 The paper presents an investigation on transformer current protection with blocking against magnetizing inrush current in short circuit fault modes. It has been shown that the proposed magnetizing in-rush current blocking algorithm can be implemented in ...
M. S. Loman
doaj
A Practical Protection Coordination Strategy Applied to Secondary and Facility Microgrids
Energies, 2012 In a conventional distribution system, protection algorithms are designed to operate on a unidirectional high fault-current level. In a microgrid, a fault current from distributed generation (DG) may bring about a relay malfunction because of the ...
Woo-Kyu Chae +5 more
doaj +1 more source
Current protective strategies in liver surgery
World Journal of Gastroenterology, 2010 During liver resection surgery for cancer or liver transplantation, the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow), which results in liver injury [ischemia-reperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways.
Kurinchi S, Gurusamy +2 more
openaire +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Multi-Sectional Arc Eliminator for Protection of Low Voltage Electrical Equipment
Energies, 2020 The paper presents a system of two oppositely connected multi-sectional thyristor branches. The system works as a multi-sectional arc eliminator (MSAE), protecting low-voltage electrical apparatus against the effects of an arcing fault.
Karol Nowak +2 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
TESTING SOLUTIONS OF THE PROTECTION SYSTEMS PROVIDED WITH DELAY MAXIMUM CURRENT RELAYS [PDF]
Carpathian Journal of Electrical Engineering, 2017 Relay protection is one of the main forms of automation control of electro energy systems, having as primary aims fault detection and disconnection of the faulty element in order to avoid the extent of damages and the as fast as possible recovery to the ...
Horia BALAN +3 more
doaj
Protection of Bridges Against Stray Current Corrosion
The Baltic Journal of Road and Bridge Engineering, 2015 A case study of Siennicki Bridge stray current corrosion hazard is presented. A corrosion risk was caused by incorrectly designed tram line traction which goes over the bridge.
Krzysztof Zakowski +2 more
doaj +1 more source