Results 71 to 80 of about 929,929 (317)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Current protection [PDF]

IEEE International Conference on Electro/Information Technology, 2014
Steven Phillips, Alex N. Jensen, Steve Chiu   +2 more
openaire   +1 more source

Protection and Management of Species, Habitats, Ecosystems and Landscapes: Current Trends and Global Needs [PDF]

, 2020
Panayotis Dimopoulos, Ioannis Kokkoris
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Method for Detection and Limitation of Short-Circuit Currents for Semiconductor Circuit Breakers in LVDC Grids Using a Pre-Saturated Inductor

IEEE Open Journal of Power Electronics
This paper introduces an innovative non-destructive device designed to detect and limit short-circuit currents in LVDC grids. The proposed solution utilizes a transformer fully saturated by a permanent magnet during normal operation. When a short-circuit
Johannes Gehring, Raffael Schwanninger, Alexander Nowak, Bernd Wunder, Vincent Lorentz, Martin Marz   +5 more
doaj   +1 more source

Serbia: Current Risks in Heritage Protection

, 2017
Heritage at Risk, H@R 2014 ...
Roter-Blagojević, Mirjana, Nikolić, Marko, Vukotić-Lazar, Marta   +2 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

An Optimized Scheme for Active Distribution Network Current Speed Protection Setting Considering Tie Switch Operation

Zhongguo dianli
Active distribution grid with tie switches has a complex grid structure and undergo frequent changes in operation mode, which greatly affects the correct operation of traditional current protection that relies on static grid topology and fixed operation ...
Nuo CHENG, Dacai CHEN, Xue CHEN, Xiaofei RUAN, Shuqing WEI, Zheyu HAN   +5 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source