Results 81 to 90 of about 3,825,314 (291)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Protection Criteria of Cathodically Protected Pipelines Under AC Interference

Corrosion and Materials Degradation
Carbon steel structures employed to convey hydrocarbons and other dangerous fluids, such as oil or flammable liquids, are equipped with degradation prevention systems, which typically consist of a cathodic protection (CP) system combined with an external
Luca Paterlini, Andrea Marinelli, Andrea Brenna, Marco Ormellese   +3 more
doaj   +1 more source

'Too well-travelled', not well-formed? the reform of 'criminality information sharing' in the UK [PDF]

, 2013
The UK Supreme Court will eventually have to pass judgment on the compliance of the legal and policy framework for ‘criminality information sharing’ with the stipulations of Article 8 of the European Convention on Human Rights, and perhaps in relation ...
Grace, Jamie
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Environment protection: The current challenge in radioecology

EPJ Web of Conferences, 2012
Radioecology, a multifaceted scientific discipline which addresses environmental issues relevant to radioprotection, has for a long time been focused on environmental transfers through the environment to feed the needs of human radioprotection.
Bréchignac F.
doaj   +1 more source

ДОСЛІДЖЕННЯ ПОХИБОК ТРАНСФОРМАТОРІВ СТРУМУ У СИСТЕМАХ РЕЛЕЙНОГО ЗАХИСТУ В УСТАЛЕНИХ ТА ПЕРЕХІДНИХ РЕЖИМАХ ЕНЕРГОСИСТЕМИ

Elektrotehnìka ta Elektroenergetika, 2016
Мета роботи. Визначення максимальних величин струмових та кутових похибок трансформаторів струму та характеру їх зміни в усталених та перехідних режимах енергосистеми, за яких можливий вихід величин похибок за межі діапазону нормованих значень, а також у
V. V. Nitsenko, D. O. Kulagin, P. V. Makhlin   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Minimally Invasive Mitral Valve Surgery I: Patient Selection, Evaluation, and Planning. [PDF]

, 2016
Widespread adoption of minimally invasive mitral valve repair and replacement may be fostered by practice consensus and standardization. This expert opinion, first of a 3-part series, outlines current best practices in patient evaluation and selection ...
Agnihotri, Arvind K, Ailawadi, Gorav, Barnhart, Glenn R, Farivar, R Saeid, Fayers, Trevor M, Goldman, Scott M, Grossi, Eugene A, Guy, T Sloane, Hargrove, W Clark, Hummel, Brian W, Khan, Junaid H, Lehr, Eric J, Lewis, Clifton TP, Malaisrie, S Chris, Mehall, John R, Murphy, Douglas A, Rodriguez, Evelio, Ryan, William H, Salemi, Arash, Segurola, Romualdo J, Shemin, Richard J, Smith, J Michael, Smith, Robert L, Weldner, Paul W, Wolfe, J Alan   +24 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Characteristics of grounding performance at Taman Bukit Perdana [PDF]

, 2020
Grounding system is one of the important part during installation of power systems. The function of grounding system is to enable protection to the power system in case of any current leakage or lightning strike.
., Muhammad Saufi, Abdul Malik, Abdul Mukmin, Kamarudin, Qamarul Ezani, Mohd Jamail, Nor Akmal, Othman, Nordiana Azlin   +4 more
core