Results 131 to 140 of about 22,479,666 (360)
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Return saham represent one of factors to motivate investor and represent reward of invesment which share done. Return can assess from level of basal factor company specified period.
Dahli Suhaeli Suhaeli, Sartono Tri Tri
doaj
Penelitian ini bertujuan untuk menemukan bukti secara empiris pengaruh rasio keuangan dalam hal ini Return on Equity (ROE), Debt to Total Asset (DAR), dan Current Ratio (CR) terhadap Income smoothing dengan Tarif Pajak Efektive sebagai variable mediasi ...
Teddy Haryadi +2 more
doaj +1 more source
A numerical investigation of constant-volume non-Boussinesq density currents [PDF]
The time-dependent behaviour of non-Boussinesq high-Reynolds-number density currents of density ρc, released from a lock of height h₀ and length x₀ into a ambient of height H and density ρₐ, is considered. We use two dimensional Navier-Stokes simulations
Balachandar, Sivaramakrishnan +2 more
core
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
This research aims to analyze and provide empirical evidence of the influence of Corporate Social Responsibility, Return on Assets, Current Ratio, Total Asset Turnover, and Debt to Equity Ratio on the share prices of companies that have received the Asia
Nidya Puspithasari, Atik Emilia Sula
doaj +1 more source
ANALISIS KEBIJAKAN INVESTASI AKTIVA TETAP TERHADAP LIKUIDITAS PERUSAHAAN (Studi Kasus pada PT Bhanda Ghara Reksa Cabang Semarang) [PDF]
PT Bhanda Ghara Reksa Branch of Semarang is logistic state-owned corporation. This company has a lot of potency to conduct fix assets investment because it has much capital.
WIDODO, AHMAD ARIF
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source

