Results 41 to 50 of about 5,118,195 (304)

The Current Situation of Parasitic Infections in Indonesia [PDF]

, 1989
Parasitic infections are highly prevalent in Indonesia, especially in rural areas, suburbs and slums of big cities. Twenty two species of protozoa and 32 species of helminths have been reported infecting man in Indonesia.
Oemijati, S. (Sri)
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Application Status of the Mineral Processing Process Control System

Kuangchan zonghe liyong
With the popularization of intelligence, more and more industries have entered the threshold of intelligence, and the traditional mineral processing process also needs to carry out intelligent changes with the times. The combination of mineral processing
Zhenyue ZHANG, Jing YANG, Wenda GUO, Ling JIANG, Defeng LIU, Ru-an CHI   +5 more
doaj   +1 more source

COVID-19, an Emerging Coronavirus Infection: Current Scenario and Recent Developments - An Overview

Journal of Pure and Applied Microbiology, 2020
During December 2019, a novel coronavirus virus (2019-nCov) emerged in China, which posed an International Public Health Emergency in a couple of weeks, and very recently attained the position of a very high-risk category by World Health Organization ...
Alfonso J. Rodriguez-Morales, D. Katterine Bonilla-Aldana, Ruchi Tiwari, Ranjit Sah, Ali A. Rabaan, Kuldeep Dhama   +5 more
doaj   +1 more source

Job security among healthcare workers in Guangdong, China

Frontiers in Public Health, 2023
ObjectiveThe objective of this study was to explore the sense of job security and its influencing factors among healthcare workers in Guangdong, China.MethodsThis cross-sectional study used stratified random sampling to enroll healthcare workers employed
Qingxia He, Luís M. Dias Martins, Shibin Wang, Qishan Zhan, Xiao Yu, Zhiqiong Ba, Wangjiu Li, Huigen Huang   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Current-induced atomic forces in gated graphene nanoconstrictions [PDF]

, 2019
Electronic current densities can reach extreme values in highly conducting nanostructures where constrictions limit current. For bias voltages on the 1 volt scale, the highly non-equilibrium situation can influence the electronic density between atoms ...
Brandbyge, Mads, Leitherer, Susanne, Papior, Nick   +2 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Standardized exercise tests in horses : current situation and future perspectives [PDF]

, 2017
The purpose of this literature review is to clarify how exercise capacity can be measured in horses and which standardized exercise tests (SETs) exist. In this review, the measurement of the exercise capacity of horses is discussed and the standardized ...
Boshuizen, Berit, de Bruijn, Marco, De Maré, Lorie, Delesalle, Catherine, Plancke, Lukas   +4 more
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source