Results 51 to 60 of about 771,464 (302)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Sensors, 2019 Accurate average flow velocity determination is essential for flow measurement in many industries, including automotive, chemical, and oil and gas.
Lei Kang +6 more
doaj +1 more source
Measurement Uncertainty of Radiated Electromagnetic Emissions in In Situ Tests of Wind Energy Conversion Systems [PDF]
Advances in Radio Science, 2018 The electromagnetic (EM) emissions of wind energy conversion systems (WECS) are evaluated in situ. Results of in situ tests, however, are only valid for the examined equipment under test (EUT) and cannot be applied to series production as samples, as ...
S. Koj, A. Hoffmann, H. Garbe
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Evaluation of a Model for Predicting the Tidal Velocity in Fjord Entrances
Energies, 2013 Sufficiently accurate and low-cost estimation of tidal velocities is of importance when evaluating a potential site for a tidal energy farm. Here we suggest and evaluate a model to calculate the tidal velocity in fjord entrances.
Paul Thomassen +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Remote Sensing, 2020 Measurements of ocean surface currents in coastal waters are crucial for improving our understanding of tidal atlases, as well as for ecosystem and water pollution monitoring. This paper proposes an improved method for estimating the baseline-to-platform
Na Yi, Yijun He, Baochang Liu
doaj +1 more source
Resolution of the paradox of the diamagnetic effect on the Kibble coil
Scientific Reports, 2021 Employing very simple electro-mechanical principles known from classical physics, the Kibble balance establishes a very precise and absolute link between quantum electrical standards and macroscopic mass or force measurements.
Shisong Li +8 more
doaj +1 more source
Measurement and control systems for an imaging electromagnetic flow meter [PDF]
, 2014 Electromagnetic flow metres based on the principles of Faraday's laws of induction have been used successfully in many industries. The conventional electromagnetic flow metre can measure the mean liquid velocity in axisymmetric single phase flows ...
G. Lucas +14 more
core +1 more source