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Digital medicine and the curse of dimensionality [PDF]

open access: yesnpj Digital Medicine, 2021
Digital health data are multimodal and high-dimensional. A patient’s health state can be characterized by a multitude of signals including medical imaging, clinical variables, genome sequencing, conversations between clinicians and patients, and ...
Visar Berisha   +6 more
doaj   +5 more sources

Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis [PDF]

open access: yesLife Science Alliance, 2022
This work formulates a noise reduction method, RECODE, which resolves the curse of dimensionality in noisy high-dimensional data, including scRNA-seq data, for effective downstream analyses.
Yusuke Imoto   +9 more
doaj   +2 more sources

Fractional Norms and Quasinorms Do Not Help to Overcome the Curse of Dimensionality [PDF]

open access: yesEntropy, 2020
The curse of dimensionality causes the well-known and widely discussed problems for machine learning methods. There is a hypothesis that using the Manhattan distance and even fractional lp quasinorms (for p less than 1) can help to overcome the curse of ...
Evgeny M. Mirkes   +2 more
doaj   +2 more sources

Gene-gene interaction: the curse of dimensionality. [PDF]

open access: yesAnn Transl Med, 2019
Identified genetic variants from genome wide association studies frequently show only modest effects on the disease risk, leading to the "missing heritability" problem. An avenue, to account for a part of this "missingness" is to evaluate gene-gene interactions (epistasis) thereby elucidating their effect on complex diseases.
Chattopadhyay A, Lu TP.
europepmc   +4 more sources

Neural Mechanisms for Undoing the "Curse of Dimensionality". [PDF]

open access: yesJ Neurosci, 2015
Human behavior is marked by a sophisticated ability to attribute outcomes and events to choices and experiences with surprising nuance. Understanding the mechanisms that govern this ability is a major focus for cognitive neuroscience.
Vaidya AR.
europepmc   +4 more sources

Rigid geometry solves "curse of dimensionality" effects in clustering methods: An application to omics data. [PDF]

open access: yesPLoS ONE, 2017
The quality of samples preserved long term at ultralow temperatures has not been adequately studied. To improve our understanding, we need a strategy to analyze protein degradation and metabolism at subfreezing temperatures.
Shun Adachi
doaj   +2 more sources

TOWARDS OVERCOMING THE CURSE OF DIMENSIONALITY IN PREDICTIVE MODELLING AND UNCERTAINTY QUANTIFICATION [PDF]

open access: yesEPJ Web of Conferences, 2021
This invited presentation summarizes new methodologies developed by the author for performing high-order sensitivity analysis, uncertainty quantification and predictive modeling.
Cacuci Dan G.
doaj   +3 more sources

Unsupervised Deep Embedded Clustering for High-Dimensional Visual Features of Fashion Images

open access: yesApplied Sciences, 2023
Fashion image clustering is the key to fashion retrieval, forecasting, and recommendation applications. Manual labeling-based clustering is both time-consuming and less accurate.
Umar Subhan Malhi   +5 more
doaj   +1 more source

A model-based clustering via mixture of hierarchical models with covariate adjustment for detecting differentially expressed genes from paired design

open access: yesBMC Bioinformatics, 2023
The causes of many complex human diseases are still largely unknown. Genetics plays an important role in uncovering the molecular mechanisms of complex human diseases.
Yixin Zhang, Wei Liu, Weiliang Qiu
doaj   +1 more source

Support Vector Machine – Recursive Feature Elimination for Feature Selection on Multi-omics Lung Cancer Data

open access: yesProgress in Microbes and Molecular Biology, 2023
Biological data obtained from sequencing technologies is growing exponentially. Multi-omics data is one of the biological data that exhibits high dimensionality, or more commonly known as the curse of dimensionality.
Nuraina Syaza Azman   +6 more
doaj   +1 more source

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