Results 161 to 170 of about 267,369 (299)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Introducing the Modified Cobb Angle for Measuring Cervical Spine Curvature During Swallowing. [PDF]

Laryngoscope Investig Otolaryngol
Steele CM, Grady MO, Farpour S, Peladeau-Pigeon M, Abrams SW, Folsom M, Plowman EK, Namasivayam-MacDonald AM.   +7 more
europepmc   +1 more source

On curvatures of spaces with normal general connections. II. [PDF]

, 1963
Tominosuke Ôtsuki
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Non-erythrocyte spectrin network preferentially stabilizes flat membrane and enhances cell stiffness. [PDF]

RSC Adv
Komikawa T, Miyake T, Morooka M, Kawakami R, Saito S, Critchley K, Evans SD, Okochi M, Tanaka M.   +8 more
europepmc   +1 more source

Four-orbifolds with positive isotropic curvature [PDF]

, 2011
Hong Huang
openalex   +1 more source

ON THE POSITIVITY OF THE RICCI CURVATURE, OF THE SECTIONAL CURVATURE AND OF THE CURVATURE OPERATOR

Annals of the Alexandru Ioan Cuza University - Mathematics, 2014
openaire   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Regulation of corneal stromal cell behavior by modulating curvature using a hydraulically-controlled organ chip array. [PDF]

Nat Commun
Kim M, Choi K, Križaj D, Kim J.
europepmc   +1 more source