Results 201 to 210 of about 1,083,966 (327)

Rectilinear congruences whose developables intersect a surface in its lines of curvature [PDF]

, 1945
Claude Springer
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

ON THE POSITIVITY OF THE RICCI CURVATURE, OF THE SECTIONAL CURVATURE AND OF THE CURVATURE OPERATOR [PDF]

Annals of the Alexandru Ioan Cuza University - Mathematics, 2014
openaire   +1 more source

Three-manifolds with positive Ricci curvature

, 1982
R. Hamilton
semanticscholar   +1 more source

Revisiting CDKN2A dysregulation in Ewing sarcoma

Molecular Oncology, EarlyView.
We revisit CDKN2A to investigate its role as a potential prognostic biomarker in Ewing sarcoma using data from pre‐clinical models as well as clinical samples. Ewing sarcoma (EwS) is a rare and aggressive malignancy, which frequently affects children.
Anjali Paragji, Vivek Shastri, Elham Nasri, John A. Ligon, Leighton A. Elliott, Paul Castillo‐Caro, Jatinder K. Lamba, Elias J. Sayour, Nathan D. Seligson   +8 more
wiley   +1 more source

A STUDY OF THE ANATOMY, PATHOLOGY AND ETIOLOGY OF SCOLIOSISALSO PRESENTING THE SCOLIOTONE, AN APPARATUS FOR ELONGATING AND LESSENING THE ROTATION OF THE SPINE IN LATERAL CURVATURE. [PDF]

, 1904
Compton Riely
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Treatment of Angular Curvature of the Spine by a Plaster of Paris Jacket Applied in the Recumbent Posture [PDF]

, 1879
Thomas James Walker
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

An Application of Symbolic Methods to the Treatment of Mean Curvatures in Hyperspace [PDF]

, 1911
William Hunt Bates
openalex   +1 more source