Results 91 to 100 of about 725,568 (275)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
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Scientific ReportsThis manuscript offers an exhaustive analysis of Flexible Printed Circuits (FPCs), concentrating on enhancing their design to surmount two primary challenges. Firstly, it seeks to obviate contact with proximate components.
Longhui Meng +4 more
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Light: Advanced ManufacturingTo fulfill the requirements of high-precision common baseline measurement for multiple parameters, such as surface profiling and the curvature radius of large-aperture optical elements on the same instrument, this paper proposes a research on a high ...
Weiqian Zhao +3 more
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Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Discover Artificial IntelligenceDue to the extremely shortage of labeled data in low-resource scenario, the deep learning models are easily overfitted and extracted features failed in English dialect recognition tasks. In this article, curvature-aware gradient projection prototype meta-
Xiaomin Chen, Qing Ai
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FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Interferometric Locating the Waist of a Laser Beam
East European Journal of PhysicsAn interferometric method for determining the location of a laser beam waist has been developed, which implements the dependence of the wavefront curvature on its distance to the waist.
Vyacheslav A. Maslov +1 more
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Chiral nematic liquid crystal microlenses
Scientific Reports, 2017 Nematic liquid crystals (NLCs) of achiral molecules and racemic mixtures of chiral ones form flat films and show uniform textures between circular polarizers when suspended in sub-millimeter size grids and immersed in water. On addition of chiral dopants
Piotr Popov +4 more
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Cam Profile Surface Analysis of Swing Output Movable Teeth Cam Mechanism
工程科学与技术, 2018 Traditional cam mechanism with oscillating follower has the advantages of small size,low price,complex motion,and so on,which is widely used in printing machinery,agricultural machinery,textile machinery and automated office equipment,etc.As the ...
Jianfeng LI +3 more
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